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Adefovir Dipivoxil

产品编号:4143713
CAS NO:142340-99-6
包装规格:50 MG,100 MG
产品类别:进口试剂
品牌:Sigma-Aldrich
优惠价:立即咨询
产品编号包装单位单价(元)国内现货国外库存询价单
414371350 MG1190
4143713100 MG2200
产品别名

142340-99-6

Adefovir Dipivoxil

9-(2[bis(Pivaloyloxymethoxy)phosphorylmethoxy]ethyl)adenine

结构式
基本信息
Empirical Formula【经验(实验)分子式】
C20H32N5O8P
Molecular weight
501.47
MDL number
MFCD00869897
PubChem Substance ID【PubChem化学物质编号】
329771057
Application【应用】
Adefovir is used to treat hepatitis B infections. It is used to study organ-specific toxicity and immune mechanisms of Adefovir treatment.
Biochem/physiol Actions【生化/生理作用】
Adefovir is an antiviral acyclic nucleoside phosphonate (ANP) analog that works by blocking reverse transcriptase. It is an inhibitor of duck hepatitis B virus (DHBV) replication that inhibits covalently closed circular DNA (CCC DNA) amplification. Cytotxicity is induced by Human Renal Organic Anion Transporter 1 (hOAT1). Adefovir is an Inhibitor of edema factor (EF)-induced cAMP accumulation and changes in cytokine production in mouse primary macrophages .
Other Notes【其他说明】
Keep container tightly closed in a dry and well-ventilated place.
产品性质
biological source【生物来源】
synthetic
Assay【测定】
≥98% (HPLC)
form【形式】
solid
solubility【溶解性】
ethanol: 50 mg/mL
Mode of action【作用机制】
enzyme | inhibits
antibiotic activity spectrum【抗生素抗菌谱】
viruses
storage temp.【储存温度】
−20℃
SMILES string
CC(C)(C)C(=O)OCOP(=O)(COCCn1cnc2c(N)ncnc12)OCOC(=O)C(C)(C)C
InChI
1S/C20H32N5O8P/c1-19(2,3)17(26)30-11-32-34(28,33-12-31-18(27)20(4,5)6)13-29-8-7-25-10-24-14-15(21)22-9-23-16(14)25/h9-10H,7-8,11-13H2,1-6H3,(H2,21,22,23)
InChI key
WOZSCQDILHKSGG-UHFFFAOYSA-N
安全信息
Pictograms【象形图】
GHS07
Signal word【警示用语:】
Warning
Hazard Statements
H302 + H312 + H332
Precautionary Statements
P261 - P264 - P280 - P301 + P312 - P302 + P352 + P312 - P304 + P340 + P312
Hazard Classifications【危险分类】
Acute Tox. 4 Oral
Storage Class Code【储存分类代码】
11 - Combustible Solids
WGK
WGK 3
Personal Protective Equipment【个人防护装备】
dust mask type N95 (US), Eyeshields, Gloves
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