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AdaAhx3L3VS-CAS 389064-25-9-Calbiochem

产品编号:4143709
规格:A potent, covalent, cell-permeable, irreversible inhibitor of chymotrypsin-like (50-100 nM), trypsin-like (1-5 μM), and PGPH (0.5-1 μM) activities of the 20S proteasome.
CAS NO:389064-25-9
包装规格:250 μG
产品类别:进口试剂
品牌:Sigma-Aldrich
优惠价:立即咨询
产品价格
产品编号包装单位单价(元)国内现货国外库存询价单
4143709250 μG4920
产品别名

389064-25-9

AdaAhx3L3VS-CAS 389064-25-9-Calbiochem

Adamantane-acetyl-(6-aminohexanoyl)3-(leucinyl)3-vinyl-(methyl)-sulfone, Proteasome Inhibitor XVI

基本信息
Empirical Formula【经验(实验)分子式】
C50H88N6O8S
Molecular weight
933.33
General description【一般描述】
A cell-permeable, peptide vinyl sulfone that acts as a potent, irreversible inhibitor of proteasome activity. Covalently modifies the catalytically active β-subunits of the proteasome. Shown to inhibit the chymotrypsin-like (10-50 nM), trypsin-like (1-5 µM), and the peptidyl glutamyl peptide hydrolyzing (PGPH) (0.5-1 µM) activities of purified 20S proteasomes from rabbit muscle. Inhibits proteasomal degradation of deglycosylated MHC HLA-A2 heavy chain in US11+ cells (~50 µM).
A potent, covalent, cell-permeable, irreversible inhibitor of chymotrypsin-like (50-100 nM), trypsin-like (1-5 µM), and PGPH (0.5-1 µM) activities of the 20S proteasome.
Biochem/physiol Actions【生化/生理作用】
Cell permeable: yes
Target IC50: 50-100 nM against chymotrypsin-like activity of the 20S proteasome
Primary Target
chymotrypsin-like activity of the 20S proteasome
Product does not compete with ATP.
Reversible: no
Warning【警告】
Toxicity: Standard Handling (A)
Reconstitution【重悬】
Following reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Other Notes【其他说明】
Kessler, B.M., et al. 2001. Chem. Biol.8, 913.
Legal Information【法律信息】
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
产品性质
Quality Level【质量水平】
100
Assay【测定】
≥90% (HPLC)
form【形式】
powder
manufacturer/tradename
Calbiochem®
storage condition【储存条件】
OK to freeze
protect from light
color【颜色】
off-white
solubility【溶解性】
DMSO: 5 mg/mL
shipped in【运输】
ambient
storage temp.【储存温度】
−20℃
packaging【包装】
250 μg in Plastic ampoule
Packaged under inert gas
安全信息
Storage Class Code【储存分类代码】
11 - Combustible Solids
WGK
WGK 1
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