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α-Interferon, Mouse, Recombinant, E. coli
产品性质
Assay【测定】 | ≥95% (SDS-PAGE) |
Quality Level【质量水平】 | 100 |
form【形式】 | liquid |
Specific Activity | ≥3.5 x 104 units/mL |
manufacturer/tradename | Calbiochem® |
storage condition【储存条件】 | OK to freeze avoid repeated freeze/thaw cycles |
shipped in【运输】 | wet ice |
storage temp.【储存温度】 | −70℃ |
packaging【包装】 | 100 ku in Plastic ampoule |
基本信息
General description【一般描述】 | Recombinant, mouse α-interferon expressed in E. coli. Antiviral and anti-neoplastic agent. Suppresses bone marrow function and induces apoptotic cell death in non-melanoma skin cancer. IFN-α signaling is mediated by JAK1 and TYK2 tyrosine kinases. Note: 1 KU = 1000 units. Recombinant, mouse α-interferon expressed in E. coli. Antiviral, antineoplastic agent. Expressed during the triggering stage of macrophage cytocidal activation. Suppresses bone marrow function and cell proliferation. Modulates the immune response. Also known to induce apoptotic cell death in non-melanoma skin cancer. |
Warning【警告】 | Toxicity: Standard Handling (A) |
Unit Definition【单位定义】 | One unit of interferon per ml of medium will cause a 50% inhibition of EMCV-induced cytopathic effect on mouse L929 cells. Units are determined with respect to the NIH international reference standard for mouse IFN-α. |
Other Notes【其他说明】 | Krishnan, K., et al. 1997. Eur. J. Biochem. 247, 298. Rodriquez-Villanueva, S., and McDonnel, T.J. 1995. Int. J. Cancer61, 110. Dianzani, F. 1993. Gut34, 574. Brouty-Boyce, D., and Zetter, B.R. 1990. Science208, 516. Sidky, Y.A., and Borden, E.C. 1987. Cancer Res.47, 5155. Daugherty, B.L., and Pestka, S. 1986. Methods Enzymol.119, 34. Pestka, S. 1986. Methods Enzymol.119, 14. Familletti, P.C., et al. 1981. Methods Enzymol.78, 387. Johnson, M.D., et al. 1981. Methods Enzymol.78, 394. Rubinstein, S., et al. 1981. J. Virol.37, 755. |
Legal Information【法律信息】 | CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany |
安全信息
Storage Class Code【储存分类代码】 | 10 - Combustible liquids |
WGK | WGK 1 |