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2-Chloro-1-(6-methoxy-1,2,3,4-tetrahydroquinolin-1-yl)ethan-1-one

产品编号:4142982
规格:≥95%
CAS NO:57368-84-0
包装规格:100 MG
产品类别:进口试剂
品牌:Sigma-Aldrich
优惠价:立即咨询
产品价格
产品编号包装单位单价(元)国内现货国外库存询价单
4142982100 MG1650
产品别名

57368-84-0

2-Chloro-1-(6-methoxy-1,2,3,4-tetrahydroquinolin-1-yl)ethan-1-one

Electrophilic scout fragment

Scout fragment for targetable cysteine

KB02

2-Chloro-1-(6-methoxy-3,4-dihydroquinolin-1(2H)-yl)ethan-1-one

1-(Chloroacetyl)-1,2,3,4-tetrahydro-6-quinolinyl methyl ether

结构式
基本信息
Empirical Formula【经验(实验)分子式】
C12H14ClNO2
Molecular weight
239.70
MDL number
MFCD09376367
Application【应用】
2-Chloro-1-(6-methoxy-1,2,3,4-tetrahydroquinolin-1-yl)ethan-1-one is a cysteine-reactive small-molecule fragment for chemoproteomic and ligandability studies for both traditionally druggable proteins as well as "undruggable," or difficult-to-target, proteins. This fragment electrophile, or "scout" fragment, can be used alone in fragment-based covalent ligand discovery or incorporated into bifunctional tools such as electrophilic PROTAC® molecules for targeted protein degradation as demonstrated by the Cravatt Lab Lab for E3 ligase discovery.
Other Notes【其他说明】
Technology Spotlight: Proteomic Ligandability Assessment

The Proteome-Wide Potential for Reversible Covalency at Cysteine

Electrophilic PROTACs that degrade nuclear proteins by engaging DCAF16

Proteome-wide covalent ligand discovery in native biological systems
Legal Information【法律信息】
PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license
产品性质
Quality Level【质量水平】
100
Assay【测定】
≥95%
form【形式】
chunks
storage temp.【储存温度】
2-8℃
安全信息
Storage Class Code【储存分类代码】
11 - Combustible Solids
WGK
WGK 3
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