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Nα-Tosyl-Lys Chloromethyl Ketone, Hydrochloride-CAS 4238-41-9-Calbiochem
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产品编号 | 包装单位 | 单价(元) | 国内现货 | 国外库存 | 询价单 |
4142308 | 50 MG | 1710 | |||
4142308 | 250 MG | 4520 |
产品别名
4238-41-9
Nα-Tosyl-Lys Chloromethyl Ketone, Hydrochloride-CAS 4238-41-9-Calbiochem
TLCK
基本信息
Empirical Formula【经验(实验)分子式】 | C14H21ClN2O3S · xHCl |
Molecular weight | 332.85 (free base basis) |
General description【一般描述】 | Inhibits trypsin-like serine proteases. Inactivates trypsin irreversibly without affecting chymotrypsin. Prevents nitric oxide production by activated macrophages by interfering with transcription of the iNOS gene. Blocks cell-cell adhesion and binding of HIV-1 virus to target cells. In macrophages, blocks nitric oxide synthase induced by interferon-γ and lipopolysaccharides (EC50 = 80 µM). Prevents endonucleolysis accompanying apoptotic death of HL-60 leukemic cells and normal thymocytes. Suggesting working concentration is 10-100 µM. Inhibits trypsin-like serine proteinases. Irreversibly inactivates trypsin without affecting chymotrypsin. Prevents nitric oxide production by activated macrophages by interfering with transcription of the iNOS gene. Blocks cell-cell adhesion and binding of HIV-1 virus to the target cells. In macrophages, blocks nitric oxide synthase induced by interferon-γ and lipopolysaccharides (EC50 = 80 µM). Prevents endonucleolysis accompanying apoptotic death of HL-60 leukemia cells and normal thymocytes. |
Biochem/physiol Actions【生化/生理作用】 | EC50 = 80 µM blocking nitric oxide synthase induced by interferon-γ and lipopolysaccharides in macrophages Product does not compete with ATP. Reversible: no Cell permeable: no Primary Target trypsin like proteases |
Warning【警告】 | Toxicity: Irritant (B) |
Reconstitution【重悬】 | Unstable in solution; reconstitute just prior to use. |
Other Notes【其他说明】 | Griscavage, J.M., et al. 1995. Biochem. Biophys. Res. Commun.215, 721. Kim, H., et al. 1995. J. Immunol.154, 4741. Bourinbaiar, A.S. and Nagorny, R. 1994. Cell Immunol. 155, 230. Biro, A., et al. 1992. Eur. J. Immunol.22, 2547. Bruno, S., et al. 1992. Leukemia6, 1113. Lee, S.F. 1992. Infect. Immun. 60, 4032. Schmidt, H.H., et al. 1992. Mol. Pharmacol.41, 615. |
Legal Information【法律信息】 | CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany |
产品性质
Quality Level【质量水平】 | 100 |
Assay【测定】 | ≥95% (elemental analysis) |
form【形式】 | solid |
manufacturer/tradename | Calbiochem® |
storage condition【储存条件】 | OK to freeze desiccated (hygroscopic) |
color【颜色】 | off-white |
solubility【溶解性】 | aqueous solution, pH <6.0: 1 mg/mL |
shipped in【运输】 | ambient |
storage temp.【储存温度】 | 2-8℃ |
InChI | 1S/C14H21ClN2O3S.ClH/c1-11-5-7-12(8-6-11)21(19,20)17-13(14(18)10-15)4-2-3-9-16;/h5-8,13,17H,2-4,9-10,16H2,1H3;1H/t13-;/m0./s1 |
InChI key | YFCUZWYIPBUQBD-ZOWNYOTGSA-N |
packaging【包装】 | 50, 250 mg in Plastic ampoule |
安全信息
Storage Class Code【储存分类代码】 | 11 - Combustible Solids |
WGK | WGK 3 |