广州伟伯科技有限公司
您的位置:首页 > 产品中心 > 4238-41-9, Nα-Tosyl-Lys Chloromethyl Ketone, Hydrochloride-CAS 4238-41-9-Calbiochem
产品搜索:

Nα-Tosyl-Lys Chloromethyl Ketone, Hydrochloride-CAS 4238-41-9-Calbiochem

产品编号:4142308
规格:Inhibits trypsin-like serine proteinases.
CAS NO:4238-41-9
包装规格:50 MG,250 MG
产品类别:进口试剂
品牌:Sigma-Aldrich
优惠价:立即咨询
产品编号包装单位单价(元)国内现货国外库存询价单
414230850 MG1710
4142308250 MG4520
产品别名

4238-41-9

Nα-Tosyl-Lys Chloromethyl Ketone, Hydrochloride-CAS 4238-41-9-Calbiochem

TLCK

基本信息
Empirical Formula【经验(实验)分子式】
C14H21ClN2O3S · xHCl
Molecular weight
332.85 (free base basis)
General description【一般描述】
Inhibits trypsin-like serine proteases. Inactivates trypsin irreversibly without affecting chymotrypsin. Prevents nitric oxide production by activated macrophages by interfering with transcription of the iNOS gene. Blocks cell-cell adhesion and binding of HIV-1 virus to target cells. In macrophages, blocks nitric oxide synthase induced by interferon-γ and lipopolysaccharides (EC50 = 80 µM). Prevents endonucleolysis accompanying apoptotic death of HL-60 leukemic cells and normal thymocytes. Suggesting working concentration is 10-100 µM.
Inhibits trypsin-like serine proteinases. Irreversibly inactivates trypsin without affecting chymotrypsin. Prevents nitric oxide production by activated macrophages by interfering with transcription of the iNOS gene. Blocks cell-cell adhesion and binding of HIV-1 virus to the target cells. In macrophages, blocks nitric oxide synthase induced by interferon-γ and lipopolysaccharides (EC50 = 80 µM). Prevents endonucleolysis accompanying apoptotic death of HL-60 leukemia cells and normal thymocytes.
Biochem/physiol Actions【生化/生理作用】
EC50 = 80 µM blocking nitric oxide synthase induced by interferon-γ and lipopolysaccharides in macrophages
Product does not compete with ATP.
Reversible: no
Cell permeable: no
Primary Target
trypsin like proteases
Warning【警告】
Toxicity: Irritant (B)
Reconstitution【重悬】
Unstable in solution; reconstitute just prior to use.
Other Notes【其他说明】
Griscavage, J.M., et al. 1995. Biochem. Biophys. Res. Commun.215, 721.
Kim, H., et al. 1995. J. Immunol.154, 4741.
Bourinbaiar, A.S. and Nagorny, R. 1994. Cell Immunol. 155, 230.
Biro, A., et al. 1992. Eur. J. Immunol.22, 2547.
Bruno, S., et al. 1992. Leukemia6, 1113.
Lee, S.F. 1992. Infect. Immun. 60, 4032.
Schmidt, H.H., et al. 1992. Mol. Pharmacol.41, 615.
Legal Information【法律信息】
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
产品性质
Quality Level【质量水平】
100
Assay【测定】
≥95% (elemental analysis)
form【形式】
solid
manufacturer/tradename
Calbiochem®
storage condition【储存条件】
OK to freeze
desiccated (hygroscopic)
color【颜色】
off-white
solubility【溶解性】
aqueous solution, pH <6.0: 1 mg/mL
shipped in【运输】
ambient
storage temp.【储存温度】
2-8℃
InChI
1S/C14H21ClN2O3S.ClH/c1-11-5-7-12(8-6-11)21(19,20)17-13(14(18)10-15)4-2-3-9-16;/h5-8,13,17H,2-4,9-10,16H2,1H3;1H/t13-;/m0./s1
InChI key
YFCUZWYIPBUQBD-ZOWNYOTGSA-N
packaging【包装】
50, 250 mg in Plastic ampoule
安全信息
Storage Class Code【储存分类代码】
11 - Combustible Solids
WGK
WGK 3
广州伟伯科技有限公司 版权所有 CopyRight ©2006-2024, All Rights Reserved
工信部备案号:粤ICP备08114744号   Page Run Time: 0.0099