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MMP-2/MMP-9 Inhibitor IV-CAS 292605-14-2-Calbiochem
产品编号: | 4142299 |
规格: | The MMP-2/MMP-9 Inhibitor IV, also referenced under CAS 292605-14-2, controls the biological activity of MMP-2/MMP-9. This small molecule/inhibitor is primarily used for Protease Inhibitors applications. |
CAS NO: | 292605-14-2 |
包装规格: | 500 μG |
产品类别: | 进口试剂 |
品牌: | Sigma-Aldrich |
优惠价: | 立即咨询 |
产品价格查看更多规格...
产品编号 | 包装单位 | 单价(元) | 国内现货 | 国外库存 | 询价单 |
4142299 | 500 μG | 2930 |
产品别名
292605-14-2
MMP-2/MMP-9 Inhibitor IV-CAS 292605-14-2-Calbiochem
SB-3CT
基本信息
Empirical Formula【经验(实验)分子式】 | C15H14O3S2 |
Molecular weight | 306.40 |
MDL number | MFCD09836266 |
General description【一般描述】 | A potent, selective, slow-binding and mechanism-based inhibitor of human gelatinases, MMP-2 (Ki = 13.9 nM) and MMP-9 (Ki = 600 nM). It also exhibits a covalent mechanism based behavior in inhibition of these enzymes. This inhibitor appears to have similarity to TIMP-1 and TIMP-2 in the slow-binding component of inhibition. Shown to directly bind to the zinc in the catalytic site of MMP-2. Does not affect the activities of MMP-1 (Ki = 206 µM) MMP-3 (Ki = 15 µM), or MMP-7 (Ki = 96 µM). A potent, selective, slow-binding and mechanism-based inhibitor of human gelatinases, MMP-2 (Ki = 13.9 nM), and MMP-9 (Ki = 600 nM). This inhibitor appears to behave similarly to TIMP-1 and TIMP-2 in the slow-binding component of inhibition. Also exhibits a covalent mechanism-based behavior in inhibition of these enzymes. Binds directly to the catalytic zinc ion on MMP-2. |
Biochem/physiol Actions【生化/生理作用】 | Product does not compete with ATP. Reversible: no Cell permeable: no |
Warning【警告】 | Toxicity: Standard Handling (A) |
Other Notes【其他说明】 | Krüger, A., et al. 2005. Cancer Res.65, 3523. Kleinfeld, O., et al. 2001. J. Biol. Chem.276, 17125. Brown, S., et al. 2000. J. Am. Chem. Soc.122, 6799. |
Legal Information【法律信息】 | Sold under license of U.S. Patent 6,703,415. CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany |
产品性质
Quality Level【质量水平】 | 100 |
Assay【测定】 | ≥95% (HPLC) |
form【形式】 | solid |
potency【效能】 | 13.9 nM Ki |
manufacturer/tradename | Calbiochem® |
storage condition【储存条件】 | OK to freeze protect from light |
color【颜色】 | off-white |
solubility【溶解性】 | DMSO: 100 mg/mL |
shipped in【运输】 | ambient |
storage temp.【储存温度】 | −20℃ |
packaging【包装】 | 500 μg in Plastic ampoule Packaged under inert gas |
安全信息
Storage Class Code【储存分类代码】 | 11 - Combustible Solids |
WGK | WGK 3 |