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Imiquimod-CAS 99011-02-6-Calbiochem

产品编号:4142263
规格:An imidazoquinoline compound that acts as a potent immunomodulator and displays anti-angiogenic, anti-viral and anti-inflammatory properties.
CAS NO:99011-02-6
包装规格:250 MG
产品类别:进口试剂
品牌:Sigma-Aldrich
优惠价:立即咨询
产品编号包装单位单价(元)国内现货国外库存询价单
4142263250 MG3370
产品别名

99011-02-6

Imiquimod-CAS 99011-02-6-Calbiochem

1-(2-Methylpropyl)-1H-imidazole[4,5-c]quinoline-4-amine

基本信息
Empirical Formula【经验(实验)分子式】
C14H16N4
Molecular weight
240.30
MDL number
MFCD00866946
General description【一般描述】
An imidazoquinoline compound that acts as a potent immunomodulator and displays anti-angiogenic, anti-viral and anti-inflammatory properties. Reported to bind to the cell surface receptor, TLR7 (toll-like receptor 7), and induce the secretion of several pro-inflammatory cytokines and chemokines both in vitro and in vivo.
Biochem/physiol Actions【生化/生理作用】
Primary Target
TLR7 (toll-like receptor 7)
Product does not compete with ATP.
Reversible: no
Cell permeable: no
Warning【警告】
Toxicity: Toxic (F)
Preparation Note【制备说明】
warming to 60°C is required for complete solubilization.
Reconstitution【重悬】
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C. Upon thawing, warming may be required to resolubilize precipitated product.
Other Notes【其他说明】
Majewski, S., et al. 2005. Int. J. Dermatol.44, 14.
Gibson, S.J., et al. 2002. Cell. Immunol.218, 74.
Hemmi, H., et al. 2002. Nat. Immunol.3, 196.
Megyeri, K., et al. 1995. Mol. Cell. Biol.15, 2207.
Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
Legal Information【法律信息】
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
产品性质
Quality Level【质量水平】
100
Assay【测定】
≥98% (HPLC)
form【形式】
solid
manufacturer/tradename
Calbiochem®
storage condition【储存条件】
OK to freeze
protect from light
color【颜色】
white
solubility【溶解性】
DMSO: 3 mg/mL
shipped in【运输】
ambient
storage temp.【储存温度】
2-8℃
InChI
1S/C14H16N4/c1-9(2)7-18-8-16-12-13(18)10-5-3-4-6-11(10)17-14(12)15/h3-6,8-9H,7H2,1-2H3,(H2,15,17)
InChI key
DOUYETYNHWVLEO-UHFFFAOYSA-N
packaging【包装】
250 mg in Plastic ampoule
Packaged under inert gas
安全信息
Pictograms【象形图】
GHS06
Signal word【警示用语:】
Danger
Hazard Statements
H301 - H315 - H319
Precautionary Statements
P264 - P270 - P280 - P301 + P310 - P302 + P352 - P305 + P351 + P338
Hazard Classifications【危险分类】
Acute Tox. 3 Oral - Eye Irrit. 2 - Skin Irrit. 2
Storage Class Code【储存分类代码】
6.1A - Combustible, acute toxic Cat. 1 and 2 / very toxic hazardous materials
WGK
WGK 3
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