您的位置:首页 > 产品中心 > 133053-19-7, Gö 6983-CAS 133053-19-7-Calbiochem
Gö 6983-CAS 133053-19-7-Calbiochem
产品编号: | 4142255 |
规格: | A potent, cell-permeable, reversible, and ATP-competitive inhibitor of protein kinase C (PKC) that inhibits several PKC isozymes. |
CAS NO: | 133053-19-7 |
包装规格: | 500 μG |
产品类别: | 进口试剂 |
品牌: | Sigma-Aldrich |
优惠价: | 立即咨询 |
产品价格查看更多规格...
产品编号 | 包装单位 | 单价(元) | 国内现货 | 国外库存 | 询价单 |
4142255 | 500 μG | 2380 |
产品别名
133053-19-7
Gö 6983-CAS 133053-19-7-Calbiochem
2-[1-(3-Dimethylaminopropyl)-5-methoxyindol-3-yl]-3-(1H-indol-3-yl) maleimide, Go 6983
基本信息
Empirical Formula【经验(实验)分子式】 | C26H26N4O3 |
Molecular weight | 442.51 |
MDL number | MFCD04040031 |
General description【一般描述】 | A potent, cell-permeable, reversible, and ATP-competitive inhibitor of protein kinase C (PKC) that inhibits several PKC isozymes (IC50 = 7 nM for PKCα and PKCβ; 6 nM for PKCγ; 10 nM for PKCδ; and 60 nM for PKCζ). Gö 6983 does not effectively inhibit PKCµ (IC50 = 20 µM) and can thus be used to differentiate PKCµ from other PKC isozymes. A potent, cell-permeable, inhibitor of protein kinase C (PKC) that has been shown to selectively inhibit several PKC isozymes (IC50 = 7 nM for PKCα and PKCβ; 6 nM for PKCγ; 10 nM for PKCδ; 60 nM for PKCζ). Gö 6983 does not effectively inhibit PKCµ (IC50 = 20 µM) and can thus be used to differentiate PKCµ from other PKC isozymes. |
Biochem/physiol Actions【生化/生理作用】 | Cell permeable: yes Primary Target PKCα and PKCβ Product competes with ATP. Reversible: yes Target IC50: 7 nM for PKCα and PKCβ; 6 nM for PKCγ; 10 nM for PKCδ; and 60 nM for PKCζ |
Warning【警告】 | Toxicity: Standard Handling (A) |
Other Notes【其他说明】 | Wang, D., et al. 1998. J. Biol. Chem. 273, 33027. Stempka, L., et al. 1997. J. Biol. Chem. 272, 6805. Gschwendt, M., et al. 1996. FEBS Lett. 392, 77. |
Legal Information【法律信息】 | CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany |
产品性质
Quality Level【质量水平】 | 100 |
Assay【测定】 | ≥98% (HPLC) |
form【形式】 | solid |
manufacturer/tradename | Calbiochem® |
storage condition【储存条件】 | OK to freeze protect from light |
color【颜色】 | orange-red |
solubility【溶解性】 | DMSO: 100 mg/mL |
shipped in【运输】 | ambient |
storage temp.【储存温度】 | −20℃ |
packaging【包装】 | 500 μg in Plastic ampoule |
安全信息
Storage Class Code【储存分类代码】 | 11 - Combustible Solids |
WGK | WGK 3 |