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Gö 6983-CAS 133053-19-7-Calbiochem

产品编号:4142255
规格:A potent, cell-permeable, reversible, and ATP-competitive inhibitor of protein kinase C (PKC) that inhibits several PKC isozymes.
CAS NO:133053-19-7
包装规格:500 μG
产品类别:进口试剂
品牌:Sigma-Aldrich
优惠价:立即咨询
产品编号包装单位单价(元)国内现货国外库存询价单
4142255500 μG2380
产品别名

133053-19-7

Gö 6983-CAS 133053-19-7-Calbiochem

2-[1-(3-Dimethylaminopropyl)-5-methoxyindol-3-yl]-3-(1H-indol-3-yl) maleimide, Go 6983

基本信息
Empirical Formula【经验(实验)分子式】
C26H26N4O3
Molecular weight
442.51
MDL number
MFCD04040031
General description【一般描述】
A potent, cell-permeable, reversible, and ATP-competitive inhibitor of protein kinase C (PKC) that inhibits several PKC isozymes (IC50 = 7 nM for PKCα and PKCβ; 6 nM for PKCγ; 10 nM for PKCδ; and 60 nM for PKCζ). Gö 6983 does not effectively inhibit PKCµ (IC50 = 20 µM) and can thus be used to differentiate PKCµ from other PKC isozymes.
A potent, cell-permeable, inhibitor of protein kinase C (PKC) that has been shown to selectively inhibit several PKC isozymes (IC50 = 7 nM for PKCα and PKCβ; 6 nM for PKCγ; 10 nM for PKCδ; 60 nM for PKCζ). Gö 6983 does not effectively inhibit PKCµ (IC50 = 20 µM) and can thus be used to differentiate PKCµ from other PKC isozymes.
Biochem/physiol Actions【生化/生理作用】
Cell permeable: yes
Primary Target
PKCα and PKCβ
Product competes with ATP.
Reversible: yes
Target IC50: 7 nM for PKCα and PKCβ; 6 nM for PKCγ; 10 nM for PKCδ; and 60 nM for PKCζ
Warning【警告】
Toxicity: Standard Handling (A)
Other Notes【其他说明】
Wang, D., et al. 1998. J. Biol. Chem. 273, 33027.
Stempka, L., et al. 1997. J. Biol. Chem. 272, 6805.
Gschwendt, M., et al. 1996. FEBS Lett. 392, 77.
Legal Information【法律信息】
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
产品性质
Quality Level【质量水平】
100
Assay【测定】
≥98% (HPLC)
form【形式】
solid
manufacturer/tradename
Calbiochem®
storage condition【储存条件】
OK to freeze
protect from light
color【颜色】
orange-red
solubility【溶解性】
DMSO: 100 mg/mL
shipped in【运输】
ambient
storage temp.【储存温度】
−20℃
packaging【包装】
500 μg in Plastic ampoule
安全信息
Storage Class Code【储存分类代码】
11 - Combustible Solids
WGK
WGK 3
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