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Anti-c-Abl (Ab-3) Mouse mAb (24-21)

产品编号:4142147
规格:liquid, clone 24-21, Calbiochem®
包装规格:100 μG
产品类别:进口试剂
品牌:Sigma-Aldrich
优惠价:立即咨询
产品价格
产品编号包装单位单价(元)国内现货国外库存询价单
4142147100 μG6190
产品别名

Anti-c-Abl (Ab-3) Mouse mAb (24-21)

Anti-p150, Anti-Abl

产品性质
Quality Level【质量水平】
100
biological source【生物来源】
mouse
antibody form【抗体形式】
purified antibody
antibody product type
primary antibodies
clone【克隆】
24-21, monoclonal
form【形式】
liquid
contains【包含】
≤0.1% sodium azide as preservative
species reactivity
human, mouse
manufacturer/tradename
Calbiochem®
storage condition【储存条件】
do not freeze
isotype【同位素/亚型】
IgG1
shipped in【运输】
wet ice
storage temp.【储存温度】
2-8℃
packaging【包装】
100 μg in Plastic ampoule
Please refer to vial label for lot-specific concentration.
基本信息
General description【一般描述】
Purified mouse monoclonal antibody generated by immunizing BALB/c mice with the specified immunogen and fusing splenocytes with p.3U1 mouse myeloma cells (see application references). Recognizes the v-Abl, the ~145-150 kDa c-Abl, the ~210 kDa Bcr-Abl (CML), and the ~190 kDa Bcr-Abl (ALL) proteins.
Anti-c-Abl (Ab-3), mouse monoclonal, clone 24-21, recognizes the ~145 kDa human and ~150 kDa mouse c-Abl. It is validated for Western blotting, immunofluorescence, and immunoprecipitation.
Recognizes the ~145 kDa human c-Abl, the ~150 kDa mouse c-Abl, v-Abl, and the Bcr/Abl translocation products in ALL (~190 kDa) and CML (~210 kDa). Does not inhibit protein tyrosine kinase activity.
  • Antibody Target Gene Symbol: ABL1
  • Target Synonym: ABL, AI325092, bcr/abl, C-ABL, C-ABL 1B, CABL1, E430008G22Rik, JTK7, MGC117749, p145Abl, p150, v-abl
  • Entrez Gene Name: c-abl oncogene 1, receptor tyrosine kinase
  • Hu Entrez ID: 25 (Related Antibodies: PK1006PK1013OP19)
  • Mu Entrez ID: 11350
  • Rat Entrez ID: 311860
  • Immunogen【免疫原】
    a recombinant protein consisting of the carboxyl region of v-abl protein fused to TrpE
    Application【应用】
    Immunoblotting (1-5 µg/ml)

    Immunofluorescence (see application references)

    Immunoprecipitation (1-2 µg/sample)

    Neutralization Studies (not recommended)
    Warning【警告】
    Toxicity: Standard Handling (A)
    Physical form【外形】
    In 0.05 M sodium phosphate buffer, 0.2% gelatin, pH 7.5.
    Analysis Note【分析说明】
    Positive Control
    K562 (human bcr/abl), HL-60 (normal abl), and ANN-1 (murine abl) cells
    Other Notes【其他说明】
    Does not inhibit protein tyrosine kinase activity. Detects human c-Abl (145 kDa), mouse c-Abl (150 kDa), v-Abl, and the Bcr/Abl translocation products in ALL (~210 kDa) and CML (~190 kDa). HL-60 and NIH3T3 cells contain normal, non-rearranged protein. Antibody should be titrated for optimal results in individual sample types.
    Wiedemann, L.M., et al. 1988. Blood71, 349.
    Stam, K., et al. 1985. N. Engl. J. Med.313, 1429.
    Konopka, J.B., et al. 1984. Cell37, 1035.
    Prywes, R., et al. 1983. Cell34, 569.
    de Klein, A., et al. 1982. Nature300, 765.
    Reynolds, F.H., Jr., et al. 1980. J. Virol.36, 374.
    Reynolds, F.H., Jr., et al. 1978. Proc. Natl. Acad. Sci. USA75, 3974.
    Witte, O.N., et al. 1978. Proc. Natl. Acad. Sci. USA75, 2488.
    Abelson, H.T. and Rabstein, L.S. 1970. Cancer Res.30, 2213.
    Legal Information【法律信息】
    CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
    安全信息
    Storage Class Code【储存分类代码】
    12 - Non Combustible Liquids
    WGK
    nwg
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