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ZAK, active, GST tagged human

产品编号:4141577
规格:PRECISIO® Kinase, recombinant, expressed in baculovirus infected Sf9 cells, ≥70% (SDS-PAGE), buffered aqueous glycerol solution
包装规格:10 μG
产品类别:进口试剂
品牌:Sigma-Aldrich
优惠价:立即咨询
产品价格
产品编号包装单位单价(元)国内现货国外库存询价单
414157710 μG6580
产品别名

ZAK, active, GST tagged human

MLTK

mlklak

MRK

MLK7

MLT

AZK

基本信息
NACRES
NA.32
General description【一般描述】
ZAK is a member of the MAPKKK family of signal transduction molecules and mediates gamma radiation signaling leading to cell cycle arrest. The activity of ZAK plays a role in cell cycle checkpoint regulation as well as being involved in regulating actin organization. Expression of kinase-dead ZAK in mouse fibroblasts disrupts actin stress fibers and causes morphologic changes. ZAK can activate JNK through MKK4/MKK7 and ERK5/p38-gamma via MKK3/MKK6. Expression of ZAK increases the population of cells in the G2/M phase of the cell cycle, whereas dominant-negative ZAK attenuated the G2 arrest caused by gamma radiation.
Physical form【外形】
Supplied in 50mM Tris-HCl, pH 7.5, 150mM NaCl, 10mM glutathione, 0.1mM EDTA, 0.25mM DTT, 0.1mM PMSF, 25% glycerol.
Preparation Note【制备说明】
after opening, aliquot into smaller quantities and store at -70 ℃. Avoid repeating handling and multiple freeze/thaw cycles
Legal Information【法律信息】
PRECISIO is a registered trademark of sigma-aldrich Co. LLC
产品性质
recombinant【重组】
expressed in baculovirus infected Sf9 cells
product line【产品线】
PRECISIO® Kinase
Assay【测定】
≥70% (SDS-PAGE)
form【形式】
buffered aqueous glycerol solution
Specific Activity
53-71 nmol/min·mg
mol wt【分子量】
~82 kDa
NCBI accession no.【NCBI登记号】
NM_133646
shipped in【运输】
dry ice
storage temp.【储存温度】
−70℃
Gene Information
human ... ZAK(51776)
安全信息
Storage Class Code【储存分类代码】
10 - Combustible liquids
WGK
WGK 1
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