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XIAP Active human

产品编号:4141567
规格:recombinant, expressed in baculovirus infected insect cells, ≥65% (SDS-PAGE)
包装规格:20 μG
产品类别:进口试剂
品牌:Sigma-Aldrich
优惠价:立即咨询
产品价格
产品编号包装单位单价(元)国内现货国外库存询价单
414156720 μG7540
产品别名

XIAP Active human

X-linked inhibitor of apoptosis

Inhibitor of apoptosis protein 3

Baculoviral IAP repeat-containing protein 4 (BIRC4)

E3 ubiquitin-protein ligase XIAP (MIHA)

IAP-like protein (ILP1)

基本信息
NACRES
NA.32
General description【一般描述】
XIAP (X-linked inhibitor of apoptosis) is an anti-apoptotic protein belonging to the inhibitor of apoptosis protein (IAP) family, an evolutionary conserved protein family. XIAP contains three tandem copies of BIR (baculovirusIAP repeat) domain, which is composed of ∼70 residues. IAP family members also contain a RING (really interesting new gene) zinc finger domain in their C-terminals.
Application【应用】
Useful in conjunction with E1 and E2 for the study of enzyme kinetics, screening inhibitors, and selectivity profiling.
Biochem/physiol Actions【生化/生理作用】
XIAP (X-linked inhibitor of apoptosis) is the most potent caspase-interacting protein and inhibits both intrinsic and extrinsic pathways of apoptosis. Its up-regulation in tumor cells is linked with resistance to chemotherapy. In inflammatory breast cancer (IBC) this protein is linked with resistance to antibody-dependent cellular cytotoxicity (ADCC) driven by cetuximab and trastuzumab. Embelin, an inhibitor of XIAP, functions as an anti-tumor agent in myeloma cell line (HL-60) by suppressing the expression of XIAP. Elevated expression of XIAP in rectal cancer is associated with chemotherapy resistance.
Unit Definition【单位定义】
One unit is defined as the amount of enzyme required to transfer 1 pmol of ubiquitin to substrate/min at 37℃.
Physical form【外形】
Formulated in 25 mM Tris-HCl, pH 8.0, 100 mM NaCl, 0.05% Tween-20, 100 μg/ml FLAG peptide, 20% glycerol, and 3 mM DTT.
Preparation Note【制备说明】
Thaw on ice. Upon first thaw, briefly spin tube containing enzyme to recover full content of the tube. Aliquot enzyme into single use aliquots. Store remaining undiluted enzyme in aliquots at -70℃. Note: Enzyme is very sensitive to freeze/thaw cycles.
产品性质
biological source【生物来源】
human
recombinant【重组】
expressed in baculovirus infected insect cells
Assay【测定】
≥65% (SDS-PAGE)
form【形式】
aqueous solution
mol wt【分子量】
57 kDa
packaging【包装】
pkg of 20 μg
storage condition【储存条件】
avoid repeated freeze/thaw cycles
NCBI accession no.【NCBI登记号】
NM_001167
UniProt accession no.【UniProt登记号】
P98170
shipped in【运输】
dry ice
storage temp.【储存温度】
−70℃
Gene Information
human ... XIAP(331)
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