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VTCN1 human
| 产品编号： | 4141391 |
| 规格： | recombinant, expressed in HEK 293 cells, ≥90% (SDS-PAGE) |
| 包装规格： | 10 μG，50 μG |
| 产品类别： | 进口试剂 |
| 品牌： | Sigma-Aldrich |
| 优惠价： | 立即咨询 |
产品别名
VTCN1 human
B7-H4
B7S1
B7h.5
基本信息
| NACRES | NA.32 |
| General description【一般描述】 | V-set domain-containing T-cell activation inhibitor 1 (VTCN1) is also known as Immune costimulatory protein B7-H4, Protein B7S1, T-cell costimulatory molecule B7x, B7H4, which belongs to the immunoglobulin superfamily and BTN/MOG family. VTCN1 contains two Ig-like V-type (immunoglobulin-like) domains. The expression of VTCN1 is up-regulated by IL6 and IL10 and is inhibited by GM-CSF and IL4 on antigen-presenting cells (APCs). VTCN1 / B7-H4 negatively regulates T-cell-mediated immune response by inhibiting T-cell activation, proliferation, cytokine production and development of cytotoxicity. VTCN1 involved in promoting epithelial cell transformation. |
| Physical form【外形】 | Lyophilized from 0.22 μm filtered solution in PBS, pH 7.4. Generally 5-8% Mannitol or trehalose is added as a protectant before lyophilization. |
| Reconstitution【重悬】 | Centrifuge the vial prior to opening. Reconstitute in sterile PBS, pH 7.4 to a concentration of 50 μg/mL. Do not vortex. This solution can be stored at 2-8℃ for up to 1 month. For extended storage, it is recommended to store at -20℃. |
产品性质
| biological source【生物来源】 | human |
| recombinant【重组】 | expressed in HEK 293 cells |
| tag【标签】 | 6-His tagged (C-terminus) |
| Assay【测定】 | ≥90% (SDS-PAGE) |
| form【形式】 | lyophilized |
| mol wt【分子量】 | calculated mol wt 26.1 kDa observed mol wt 45-60 kDa (DTT-reduced. Protein migrates due to glycosylation. Phe 29 is the predicted N-terminal.) |
| packaging【包装】 | pkg of 10 μg pkg of 50 μg |
| UniProt accession no.【UniProt登记号】 | Q7Z7D3 |
| shipped in【运输】 | wet ice |
| storage temp.【储存温度】 | −20℃ |
| Gene Information | human ... VTCN1(79679) |
安全信息
| Storage Class Code【储存分类代码】 | 11 - Combustible Solids |
| WGK | WGK 3 |
