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Viloxazine hydrochloride
产品别名
35604-67-2
Viloxazine hydrochloride
2-[(2-Ethoxyphenoxy)methyl]morpholinium chloride
I.C.I. 58,834 HCl
ICI 58,834 HCl
Viloxazine HCl
2-(o-Ethoxyphenoxymethyl)morpholine hydrochloride
SPN-812
2-((2-Ethoxyphenoxy)methyl)morpholine hydrochloride
rac Viloxazine HCl
1. 2-(2-Ethoxyphenoxymethyl-2,3,5,6-tetrahydro-1,4-oxazine hydrochloride salt
rac Viloxazine hydrochloride
结构式
基本信息
| Empirical Formula【经验(实验)分子式】 | C13H19NO3 · HCl |
| Molecular weight | 273.76 |
| MDL number | MFCD00661100 |
| Biochem/physiol Actions【生化/生理作用】 | Viloxazine (ICI 58,834) is an orally active serotonin norepinephrine modulating agent (SNMA) originally reported as a norepinephrine reuptake inhibitor (NRI) with antidepressant (ED10 from 0.3-1 mg/kg p.o. against reserpine-induced hypothermia in mice), while exhibiting less sedative efficacy (locomotor activity reduction ED10 from 3-10 mg/kg p.o. in mice) and no monoamine oxidase inhibitory potency. Viloxazine shows 5-HT2B antagonist and 5-HT2C agonist activity in vitro and increases extracellular 5-HT levels in the prefrontal cortex (PFC) in vivo, a brain area implicated in Attention deficit hyperactivity disorder (ADHD). |
产品性质
| Quality Level【质量水平】 | 100 |
| Assay【测定】 | ≥95% (HPLC) |
| form【形式】 | powder |
| color【颜色】 | white to beige |
| solubility【溶解性】 | DMSO: 2 mg/mL, clear |
| storage temp.【储存温度】 | 2-8℃ |
| SMILES string | CCOC1=C(OCC2OCCNC2)C=CC=C1.Cl |
安全信息
| Pictograms【象形图】 | GHS07 |
| Signal word【警示用语：】 | Warning |
| Hazard Statements | H302 |
| Precautionary Statements | P264 - P270 - P301 + P312 - P501 |
| Hazard Classifications【危险分类】 | Acute Tox. 4 Oral |
| Storage Class Code【储存分类代码】 | 11 - Combustible Solids |
| WGK | WGK 1 |
