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TSLP 人

TSLP human
产品编号:4141230
规格:recombinant, expressed in E. coli, ≥97% (SDS-PAGE), ≥97% (HPLC)
包装规格:20 μG
产品类别:进口试剂
品牌:Sigma-Aldrich
优惠价:立即咨询
产品价格
产品编号包装单位单价(元)国内现货国外库存询价单
414123020 μG5740
产品别名

TSLP 人

TSLP human

Thymic stromal lymphopoietin

基本信息
NACRES
NA.32
General description【一般描述】
Thymic stromal lymphopoietin (TSLP) is a hemopoietic cytokine. It is part of the interleukin-2 (IL-2) cytokine family. It is mainly expressed in the heart, liver and prostate. TSLP is related in its biological activities to interleukin-7 (IL-7) and binds with the heterodimeric receptor complex consisting of interleukin-7 receptor α chain & the TSLP receptor. Recombinant human TSLP produced in Escherichia coli is a single, non-glycosylated polypeptide chain containing 132 amino acids and having a molecular mass of 15kDa.
Application【应用】
TSLP human has been used in immunohistochemistry.
Biochem/physiol Actions【生化/生理作用】
Thymic stromal lymphopoietin (TSLP) signals throughout a heterodimeric receptor complex composed of the thymic stromal lymphopoietin receptor and the interleukin-7 (IL-7) receptor a chain. TSLP impacts myeloid cells and thus induces the discharge of T cell-attracting chemokines from monocytes and increases the growth of CD11c+ dendritic cells. Similar to IL-7, TSLP enhances phosphorylation of signal transducer and activator of transcription 3 and 5 (STAT3 and STAT5), though uses kinases excluding Janus kinases (JAKs) for its activation. TSLP induces the release of T cell-attracting chemokines such as thymus and activation-regulated chemokine (TARC) and macrophage-derived chemokine (MDC) from monocytes and triggers CD11c+ dendritic cells. TSLP activated dendritic cells primes naive T cells to manufacture pro-allergic cytokines such as interleukin-4, interleukin-5, interleukin-13 and tumor necrosis factor-α (TNF-α), whereas down-regulating interleukin-10 and interferon-γ (IFN-γ) play a role in the initiation of allergic inflammation.
Physical form【外形】
Lyophilized from a concentrated solution (1 mg/ml) containing 130 mM NaCl, and 20 mM sodium phosphate, pH 7.4.
Reconstitution【重悬】
Reconstitute in sterile dH2O to a concentration of 0.1 -1 mg/mL and let the lyophilized pellet dissolve completely. This solution can then be diluted into other aqueous buffers.
Centrifuge the vial prior to opening. Avoid freeze-thaw cycles.
产品性质
biological source【生物来源】
human
recombinant【重组】
expressed in E. coli
Assay【测定】
≥97% (HPLC)
≥97% (SDS-PAGE)
form【形式】
lyophilized
potency【效能】
<0.3 ng/mL ED50
mol wt【分子量】
~15.0 kDa
packaging【包装】
pkg of 20 μg
storage condition【储存条件】
avoid repeated freeze/thaw cycles
impurities【杂质】
endotoxin, tested
NCBI accession no.【NCBI登记号】
Q969D9
shipped in【运输】
wet ice
storage temp.【储存温度】
−20℃
Gene Information
human ... TSLP(85480)
安全信息
Storage Class Code【储存分类代码】
13 - Non Combustible Solids
WGK
WGK 3
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