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TRKA (G667C), Active
产品性质
| recombinant【重组】 | expressed in baculovirus infected Sf9 cells |
| Assay【测定】 | 70-95% (SDS-PAGE) |
| form【形式】 | frozen liquid |
| Specific Activity | 20-30 nmol/min·mg (radiometric) |
| mol wt【分子量】 | ~66 kDa |
| concentration【浓度】 | 0.05 μg/μL |
| accession no.【登记号】 | NM_002529 |
| shipped in【运输】 | dry ice |
| storage temp.【储存温度】 | −70℃ |
| Gene Information | human ... TRKA(4914) |
基本信息
| Application【应用】 | Useful for kinase assay. |
| Biochem/physiol Actions【生化/生理作用】 | Recombinant human TRKA (G667C) (440-end) was expressed by Baculovirus in Sf9 insect cells using an N-terminal GST tag. TRKA is a member of the trk proto-oncogene family and encodes a 140kDa, membrane-spanning protein tyrosine kinase that is the functional receptor for nerve growth factor (NGF). NGF elicits the rapid phosphorylation of gp140trk on tyrosine residues leading to increased c-Fos expression, DNA synthesis and morphologic transformation (1). A decreased expression of TRKA on the striatal cholinergic neurons has been observed which may contribute, when it reaches a crucial threshold, to the death of cholinergic neurons observed in Alzheimer disease (2). |
| Reconstitution【重悬】 | Formulated in 50mM Tris-HCl, pH 7.5, 150mM NaCl, 10mM glutathione, 0.1mM EDTA, 0.25 mM DTT, 0.1 mM PMSF, with 25% glycerol. |
| Legal Information【法律信息】 | PRECISIO is a registered trademark of sigma-aldrich Co. LLC |
产品说明
| Storage and Stability【储存及稳定性】 | Store in aliquots at -70℃. Avoid freeze/thaw cycles. |
安全信息
| Storage Class Code【储存分类代码】 | 10 - Combustible liquids |
| WGK | WGK 1 |
