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Tim-4 (human): FC (human)
产品编号: | 4141034 |
规格: | recombinant, expressed in CHO cells, ≥98% (SDS-PAGE) |
包装规格: | 100 μG |
产品类别: | 进口试剂 |
品牌: | Sigma-Aldrich |
优惠价: | 立即咨询 |
产品别名
Tim-4 (human): FC (human)
TIMD4
PC cell-derived growth factor
TIM4
基本信息
NACRES | NA.32 |
General description【一般描述】 | The TIM (T cell/transmembrane, immunoglobulin and mucin) family plays a critical role in regulating immune responses, including allergy, asthma, transplant tolerance, autoimmunity and the response to viral infections. The unique structure of TIM immunoglobulin variable region domains allows highly specific recognition of phosphatidylserine (PtdSer), exposed on the surface of apoptotic cells. TIM-4 (T cell; immunoglobulin; Mucin-4), also known as SMUCKLER, is a 60 kDa member of the TIM family of immune regulating proteins. TIM-4 is exclusively expressed on antigen-presenting cells, where it mediates phagocytosis of apoptotic cells and plays an important role in maintaining tolerance. TIM-4 binds specifically to TIM-1 which is also the cellular receptor for the hepatitis A virus, and has been implicated in the development of asthma. Among hematopoietic cells, TIM-1 is expressed on activated B and T cells, preferentially in the Th2 subset of CD4+ T cells. The interaction of TIM-4 with TIM-1 induces costimulatory and hyperproliferative signals in T cells. |
Physical form【外形】 | Lyophilized from 0.2 μm-filtered solution in PBS. |
Reconstitution【重悬】 | Reconstitute at 100 μg/mL in sterile PBS. |
Other Notes【其他说明】 | The extracellular domain of mouse Tim-4 (aa 22-279) is fused to the N-terminus of the Fc region of human IgG1. |
产品性质
biological source【生物来源】 | human |
recombinant【重组】 | expressed in CHO cells |
Assay【测定】 | ≥98% (SDS-PAGE) |
form【形式】 | lyophilized |
mol wt【分子量】 | monomer 54 kDa by calculation |
packaging【包装】 | pkg of 100 μg |
impurities【杂质】 | <0.06 EU/μg endotoxin, tested |
color【颜色】 | white |
UniProt accession no.【UniProt登记号】 | Q96H15 |
shipped in【运输】 | wet ice |
storage temp.【储存温度】 | −20℃ |
Gene Information | mouse ... Timd4(276891) |
安全信息
Storage Class Code【储存分类代码】 | 12 - Non Combustible Liquids |
WGK | WGK 2 |