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Tim-1 (human): FC (human)
产品编号: | 4141028 |
规格: | recombinant, expressed in CHO cells, ≥98% (SDS-PAGE) |
包装规格: | 100 μG |
产品类别: | 进口试剂 |
品牌: | Sigma-Aldrich |
优惠价: | 立即咨询 |
产品别名
Tim-1 (human): FC (human)
KIM1
TIMD1
hepatitis A virus cellular receptor 1
T-cell immunoglobulin and mucin domain-containing protein 4
T-cell immunoglobulin and mucin domain-containing protein 1
产品性质
biological source【生物来源】 | human |
recombinant【重组】 | expressed in CHO cells |
Assay【测定】 | ≥98% (SDS-PAGE) |
form【形式】 | lyophilized |
mol wt【分子量】 | monomer 57 kDa by calculation |
packaging【包装】 | pkg of 100 μg |
storage condition【储存条件】 | avoid repeated freeze/thaw cycles |
impurities【杂质】 | <0.06 EU/μg endotoxin, tested |
color【颜色】 | white |
UniProt accession no.【UniProt登记号】 | Q96D42 |
shipped in【运输】 | wet ice |
storage temp.【储存温度】 | −20℃ |
Gene Information | human ... HAVCR1(26762) |
基本信息
General description【一般描述】 | The TIM (T cell/transmembrane, immunoglobulin and mucin) family plays a critical role in regulating immune responses, including allergy, asthma, transplant tolerance, autoimmunity and the response to viral infections. The unique structure of TIM immunoglobulin variable region domains allows highly specific recognition of phosphatidylserine (PtdSer), exposed on the surface of apoptotic cells. TIM-1 (T cell-immunoglobulinmucin; also KIM-1 and HAVcr-1) is a 100 kDa, type I transmembrane glycoprotein member of the TIM family of immunoglobulin superfamily molecules. There are two cytoplasmic alternate splice forms of TIM1. One is a long (359 aa) kidney form termed TIM-1b, and one is a short (334 aa) liver form termed TIM-1a. TIM-1, important for asthma and allergy, is preferentially expressed on T-helper 2 (Th2) cells and functions as a potent costimulatory molecule for T cell activation. |
Physical form【外形】 | Lyophilized from 0.2 μm-filtered solution in PBS. |
Reconstitution【重悬】 | Reconstitute at 100 μg/mL in sterile PBS. |
Other Notes【其他说明】 | The extracellular domain of human Tim-1 (aa 21-295) is fused to the N-terminus of the Fc region of human IgG1. |
安全信息
Storage Class Code【储存分类代码】 | 12 - Non Combustible Liquids |
WGK | WGK 2 |