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TAF1 (1371-1496) GST tag human
产品编号: | 4140843 |
规格: | recombinant, expressed in E. coli, ≥95% (SDS-PAGE) |
包装规格: | 20 μG,100 μG |
产品类别: | 进口试剂 |
品牌: | Sigma-Aldrich |
优惠价: | 立即咨询 |
产品别名
TAF1 (1371-1496) GST tag human
BA2R
TATA Box Binding Protein (TBP)-Associated Factor
CCGS
DYT3
NSCL2
TAFII250
XDP
TAF1 RNA Polymerase II
TAF2A
KAT4
CCG1
基本信息
NACRES | NA.32 |
General description【一般描述】 | The acetylation of histone lysine residues plays a crucial role in the epigenetic regulation of gene transcription. A bromodomain is a protein domain that recognizes acetylated lysine residues such as those on the N-terminal tails of histones. This recognition is often a prerequisite for protein-histone association and chromatin remodeling. These domains function in the linking of protein complexes to acetylated nucleosomes, thereby controlling chromatin structure and gene expression. Thus, bromodomains serve as “readers” of histone acetylation marks regulating the transcription of target promoters. TAF1 is a component of transcription factor IID, and binds to core promoter sequences at the transcription start site. TAF1 helps control transcription by both its kinase and histone acetyltransferase enzymatic activities. It interacts with transcriptional activators such as the androgen receptor to promote transcription. Disruption of TAF1 causes dystonia 3 (X-linked torsion dystonia) and decreased apoptosis. This protein product contains the first bromodomain of TAF1. |
Physical form【外形】 | 50 mM Tris, pH 7.5, containing 500 mM sodium chloride, 5 mM β-mercaptoethanol and 5% glycerol. |
产品性质
biological source【生物来源】 | human |
recombinant【重组】 | expressed in E. coli |
Assay【测定】 | ≥95% (SDS-PAGE) |
form【形式】 | liquid |
mol wt【分子量】 | 41.7 kDa (1371-1496 aa + NT GST Tag) |
packaging【包装】 | pkg of 100 μg pkg of 20 μg |
UniProt accession no.【UniProt登记号】 | P21675 |
shipped in【运输】 | dry ice |
storage temp.【储存温度】 | −70℃ |
Gene Information | human ... TAF1(6872) |
安全信息
Pictograms【象形图】 | GHS07 |
Signal word【警示用语:】 | Warning |
Hazard Statements | H317 - H319 - H412 |
Precautionary Statements | P273 - P280 - P305 + P351 + P338 - P333 + P313 - P337 + P313 |
Hazard Classifications【危险分类】 | Aquatic Chronic 3 - Eye Irrit. 2 - Skin Sens. 1 |
Storage Class Code【储存分类代码】 | 13 - Non Combustible Solids |
WGK | WGK 3 |