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t-Boc-N-amido-dPEG®8-acid

产品编号:4140840
规格:>95% (HPLC)
包装规格:100 MG
产品类别:进口试剂
品牌:Sigma-Aldrich
优惠价:立即咨询
产品价格
产品编号包装单位单价(元)国内现货国外库存询价单
4140840100 MG2230
产品别名

t-Boc-N-amido-dPEG®8-acid

t-Boc-N-amido-PEG8-COOH

t-Boc-N-amido-PEG8-acid

BocNH-PEG8-CH2CH2COOH

t-Boc-PEG-acid

结构式
基本信息
Empirical Formula【经验(实验)分子式】
C24H47NO12
Molecular weight
541.63
MDL number
MFCD13185254
Features and Benefits【特点和优势】
t-Boc-N-amido-dPEG8-acid is a monodisperse PEG product that is useful for peptide synthesis. The 28-atoms-long dPEG spacer allows the introduction of a short, hydrophilic spacer onto either end of a peptide chain or on an amino acid side chain. The flexible dPEG spacer conjugates to peptides using conventional peptide synthesis chemistry. The Boc protecting group removes easily with acids such as trifluoroacetic acid (TFA), HF, and trifluoromethane sulfonic acid (TFMSA). Peptide PEGylation imparts water solubility to hydrophobic peptide chains, expands the PEG-peptide conjugates′ hydrodynamic volumes (thus decreasing renal clearance), and protects PEGylated peptides from proteolysis. The combination of decreased renal clearance and protection from proteolysis contributes to longer in vivo circulation times for PEGylated (as compared to non-PEGylated) peptides. Additionally, PEGylation diminishes a peptide′s antigenicity. This product is part of the t-Boc-N-amido-dPEGn-acid (n=4, 8, 12, 24, 36) product series.
Legal Information【法律信息】
Products Protected under U.S. Patent #s 7,888,536 & 8,637,711 and European Patent #s 1,594,440 & 2,750,681
dPEG is a registered trademark of Quanta BioDesign
产品性质
Assay【测定】
>95% (HPLC)
form【形式】
solid or viscous liquid
reaction suitability
reaction type: Pegylations
polymer architecture【聚合物结构设计】
shape: linear
functionality: heterobifunctional
shipped in【运输】
ambient
storage temp.【储存温度】
−20℃
安全信息
Storage Class Code【储存分类代码】
11 - Combustible Solids
WGK
WGK 3
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