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t-Boc-N-amido-dPEG®8-acid
产品别名
t-Boc-N-amido-dPEG®8-acid
t-Boc-N-amido-PEG8-COOH
t-Boc-N-amido-PEG8-acid
BocNH-PEG8-CH2CH2COOH
t-Boc-PEG-acid
结构式
基本信息
Empirical Formula【经验(实验)分子式】 | C24H47NO12 |
Molecular weight | 541.63 |
MDL number | MFCD13185254 |
Features and Benefits【特点和优势】 | t-Boc-N-amido-dPEG8-acid is a monodisperse PEG product that is useful for peptide synthesis. The 28-atoms-long dPEG spacer allows the introduction of a short, hydrophilic spacer onto either end of a peptide chain or on an amino acid side chain. The flexible dPEG spacer conjugates to peptides using conventional peptide synthesis chemistry. The Boc protecting group removes easily with acids such as trifluoroacetic acid (TFA), HF, and trifluoromethane sulfonic acid (TFMSA). Peptide PEGylation imparts water solubility to hydrophobic peptide chains, expands the PEG-peptide conjugates′ hydrodynamic volumes (thus decreasing renal clearance), and protects PEGylated peptides from proteolysis. The combination of decreased renal clearance and protection from proteolysis contributes to longer in vivo circulation times for PEGylated (as compared to non-PEGylated) peptides. Additionally, PEGylation diminishes a peptide′s antigenicity. This product is part of the t-Boc-N-amido-dPEGn-acid (n=4, 8, 12, 24, 36) product series. |
Legal Information【法律信息】 | Products Protected under U.S. Patent #s 7,888,536 & 8,637,711 and European Patent #s 1,594,440 & 2,750,681 dPEG is a registered trademark of Quanta BioDesign |
产品性质
Assay【测定】 | >95% (HPLC) |
form【形式】 | solid or viscous liquid |
reaction suitability | reaction type: Pegylations |
polymer architecture【聚合物结构设计】 | shape: linear functionality: heterobifunctional |
shipped in【运输】 | ambient |
storage temp.【储存温度】 | −20℃ |
安全信息
Storage Class Code【储存分类代码】 | 11 - Combustible Solids |
WGK | WGK 3 |