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STAT4 human

产品编号:4140740
规格:recombinant, expressed in insect cells, ≥85% (SDS-PAGE)
包装规格:10 μG
产品类别:进口试剂
品牌:Sigma-Aldrich
优惠价:立即咨询
产品价格
产品编号包装单位单价(元)国内现货国外库存询价单
414074010 μG5410
产品别名

STAT4 human

SLEB11

基本信息
NACRES
NA.26
Biochem/physiol Actions【生化/生理作用】
Signal transducer and activator of transcription (STAT) proteins are a family of latent cytoplasmic transcription factors involved in cytokine, hormone, and growth factor signal transduction. Seven members of the STAT family of transcription factors have been identified in mammalian cells: STAT1, STAT2, STAT3, STAT4, STAT5a, STAT5b, and STAT6. STAT proteins mediate broadly diverse biologic processes, including cell growth, differentiation, apoptosis, fetal development, transformation, inflammation, and immune response. Receptor-recruited STATs are phosphorylated on a single tyrosine residue in the carboxy terminal portion. The modified STATs are released from the cytoplasmic region of the receptor subunits to form homodimers or heterodimers through reciprocal interaction between the phosphotyrosine of one STAT and the SH2 domain of another. Following dimerization, STATs rapidly translocate to the nucleus and interact with specific regulatory elements to induce target gene transcription. Recently, STAT-1 has been implicated in modulating pro- and anti-apoptotic genes following several stress-induced responses. These effects are dependent on STAT-1 phosphorylation on serine-727 and require the C-terminal transactivation domain of STAT-1 to enhance its pro-apoptotic effect or inhibit its anti-apoptotic effects. The STAT-1 C-terminal domain has been demonstrated to be important for protein-protein interaction with other transcriptional activators. The reports that STAT-1-deficient mice develop spontaneous and chemically induced tumours more rapidly compared to wild-type mice and that STAT-1-deficient cells are more resistant to agents that induce apoptosis strongly support the argument that STAT-1 acts as a tumour suppressor.
Physical form【外形】
Clear and colorless frozen liquid solution
Preparation Note【制备说明】
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. While working, please keep sample on ice.
产品性质
biological source【生物来源】
human
recombinant【重组】
expressed in insect cells
Assay【测定】
≥85% (SDS-PAGE)
form【形式】
frozen liquid
mol wt【分子量】
~87.7 kDa
packaging【包装】
pkg of 10 μg
storage condition【储存条件】
avoid repeated freeze/thaw cycles
concentration【浓度】
500 μg/mL
color【颜色】
clear colorless
NCBI accession no.【NCBI登记号】
NM_003151
UniProt accession no.【UniProt登记号】
Q14765
shipped in【运输】
dry ice
storage temp.【储存温度】
−70℃
Gene Information
human ... STAT4(6775)
安全信息
Storage Class Code【储存分类代码】
10 - Combustible liquids
WGK
WGK 1
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