您的位置：首页 > 产品中心 > 184379-52-0， SMAD3, GST tagged human
SMAD3, GST tagged human
| 产品编号： | 4140617 |
| 规格： | recombinant, expressed in E. coli, ≥70% (SDS-PAGE), buffered aqueous glycerol solution |
| CAS NO： | 184379-52-0 |
| 包装规格： | 50 μG |
| 产品类别： | 进口试剂 |
| 品牌： | Sigma-Aldrich |
| 优惠价： | 立即咨询 |
产品别名
184379-52-0
SMAD3, GST tagged human
DKFZp686J10186
JV15-2
HsT17436
MADH3
HSPC193
MGC60396
DKFZp586N0721
基本信息
| NACRES | NA.32 |
| General description【一般描述】 | SMAD3 is a direct mediator of transcriptional activation by the TGFβ receptor. The activity of SMAD3 is regulated by the TGFβ receptors, and SMAD3 is phosphorylated and associated with the ligand-bound receptor complex. TGFβ stimulation leads to phosphorylation and activation of SMAD3, which form a complex with SMAD4 that accumulate in the nucleus and regulate transcription of target genes such as CDK inhibitor. SMAD3 containing a C-terminal truncation acts as a dominant-negative inhibitor of the normal TGFβ response. SMAD3 is a major physiologic substrate of the G1 cyclin-dependent kinases CDK4 and CDK2. |
| Physical form【外形】 | Supplied in 50mM Tris-HCl, pH 7.5, 150mM NaCl, 10mM glutathione, 0.1mM EDTA, 0.25mM DTT, 0.1mM PMSF, 25% glycerol. |
| Preparation Note【制备说明】 | after opening, aliquot into smaller quantities and store at -70 ℃. Avoid repeating handling and multiple freeze/thaw cycles |
产品性质
| biological source【生物来源】 | human |
| recombinant【重组】 | expressed in E. coli |
| Assay【测定】 | ≥70% (SDS-PAGE) |
| form【形式】 | buffered aqueous glycerol solution |
| mol wt【分子量】 | ~77 kDa |
| NCBI accession no.【NCBI登记号】 | NM_005902 |
| application(s) | cell analysis |
| shipped in【运输】 | dry ice |
| storage temp.【储存温度】 | −70℃ |
| Gene Information | human ... SMAD3(4088) |
安全信息
| Storage Class Code【储存分类代码】 | 10 - Combustible liquids |
| WGK | WGK 1 |
