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SIK (1-303), active, His tagged human
产品编号: | 4140570 |
规格: | PRECISIO® Kinase, recombinant, expressed in baculovirus infected Sf9 cells, ≥70% (SDS-PAGE), buffered aqueous glycerol solution |
包装规格: | 10 μG |
产品类别: | 进口试剂 |
品牌: | Sigma-Aldrich |
优惠价: | 立即咨询 |
产品别名
SIK (1-303), active, His tagged human
SNF1LK
msk
Sik1
基本信息
NACRES | NA.32 |
General description【一般描述】 | SIK is a protein kinase that is involved in regulating AMPK-related kinases. SIK may mediate the physiological effects of LKB1, including its tumour suppressor function. SIK is also involved in signaling by various proteins like STRAD, NUAK1, NUAK2, BRSK1, BRSK2, QIK, QSK, SIK, MARK1, MARK2, MARK3, MARK4 and MELK that are related to AMPK. Activation of SIK1 by phosphorylation on thr322 can lead to an increase in the catalytic activity of sodium/potassium ATPase alpha subunit at the plasma membrane. This results in an increase in intracellular sodium in intact mammalian cells. |
Physical form【外形】 | Supplied in 50mM sodium phosphate, pH 7.0, 300mM NaCl, 150mM imidazole, 0.1mM PMSF, 0.25mM DTT, 25% glycerol. |
Preparation Note【制备说明】 | after opening, aliquot into smaller quantities and store at -70 ℃. Avoid repeating handling and multiple freeze/thaw cycles |
Legal Information【法律信息】 | PRECISIO is a registered trademark of sigma-aldrich Co. LLC |
产品性质
recombinant【重组】 | expressed in baculovirus infected Sf9 cells |
product line【产品线】 | PRECISIO® Kinase |
Assay【测定】 | ≥70% (SDS-PAGE) |
form【形式】 | buffered aqueous glycerol solution |
Specific Activity | 296-401 nmol/min·mg |
mol wt【分子量】 | ~36 kDa |
NCBI accession no.【NCBI登记号】 | NM_173354 |
shipped in【运输】 | dry ice |
storage temp.【储存温度】 | −70℃ |
Gene Information | human ... SIK1(150094) |
安全信息
Pictograms【象形图】 | GHS07,GHS08 |
Signal word【警示用语:】 | Danger |
Hazard Statements | H315 - H319 - H360D |
Precautionary Statements | P202 - P264 - P280 - P302 + P352 - P305 + P351 + P338 - P308 + P313 |
Hazard Classifications【危险分类】 | Eye Irrit. 2 - Repr. 1B - Skin Irrit. 2 |
Storage Class Code【储存分类代码】 | 6.1C - Combustible, acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects |
WGK | WGK 1 |