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RNA Polymerase II, RPB12 subunit, GST tagged human
产品编号: | 4140394 |
规格: | recombinant, expressed in E. coli, ≥80% (SDS-PAGE) |
包装规格: | 10 μG |
产品类别: | 进口试剂 |
品牌: | Sigma-Aldrich |
优惠价: | 立即咨询 |
产品别名
RNA Polymerase II, RPB12 subunit, GST tagged human
RPB12
hsRPB10a
RPABC4
RPB10alpha
RPB7.0
hRPB7.0
ABC10-alpha
基本信息
NACRES | NA.26 |
General description【一般描述】 | POLR2K (RNA polymerase II subunit K) is located on human chromosome 8q22. Rpb12 is the eukaryotic subunit that is also called as ABC10α. Rpb12 is the general subunit of all three eukaryotic RNA polymerases. |
Biochem/physiol Actions【生化/生理作用】 | RPB12 (also called RPB10 ) is shared between all three RNA polymerases and is homologous to the archaeal P subunit of RNA polymerase. Like RPB10, it is essential for yeast cell viability. RPB12 is also a zinc-binding protein with a canonical tetra-coordinating zinc motif but binds zinc in vitro much less efficiently than the RPB10 subunit. It has been shown to interact with both RPB1 and RPB2 in vitro and the human subunit can functionally substitute for its yeast counterpart. RPB12/RPC10 (RNA polymerase II subunit K) is required for growth in Saccharomyces cerevisiae. The carboxy-terminal domain (CTD) of RNAP II plays a major role in recruiting many of these activities to the transcriptional machinery. |
Physical form【外形】 | Clear and colorless frozen liquid solution |
Preparation Note【制备说明】 | Use a manual defrost freezer and avoid repeated freeze-thaw cycles. While working, please keep sample on ice. |
产品性质
biological source【生物来源】 | human |
recombinant【重组】 | expressed in E. coli |
Assay【测定】 | ≥80% (SDS-PAGE) |
form【形式】 | frozen liquid |
mol wt【分子量】 | ~33 kDa |
packaging【包装】 | pkg of 10 μg |
storage condition【储存条件】 | avoid repeated freeze/thaw cycles |
concentration【浓度】 | 100 μg/mL |
color【颜色】 | clear colorless |
NCBI accession no.【NCBI登记号】 | NM_005034 |
UniProt accession no.【UniProt登记号】 | P53803 |
shipped in【运输】 | dry ice |
storage temp.【储存温度】 | −70℃ |
Gene Information | human ... POLR2K(5440) |
安全信息
Storage Class Code【储存分类代码】 | 10 - Combustible liquids |
WGK | WGK 1 |