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RNA Polymerase II, RPB12 subunit, GST tagged human

产品编号:4140394
规格:recombinant, expressed in E. coli, ≥80% (SDS-PAGE)
包装规格:10 μG
产品类别:进口试剂
品牌:Sigma-Aldrich
优惠价:立即咨询
产品价格
产品编号包装单位单价(元)国内现货国外库存询价单
414039410 μG5240
产品别名

RNA Polymerase II, RPB12 subunit, GST tagged human

RPB12

hsRPB10a

RPABC4

RPB10alpha

RPB7.0

hRPB7.0

ABC10-alpha

基本信息
NACRES
NA.26
General description【一般描述】
POLR2K (RNA polymerase II subunit K) is located on human chromosome 8q22. Rpb12 is the eukaryotic subunit that is also called as ABC10α. Rpb12 is the general subunit of all three eukaryotic RNA polymerases.
Biochem/physiol Actions【生化/生理作用】
RPB12 (also called RPB10 ) is shared between all three RNA polymerases and is homologous to the archaeal P subunit of RNA polymerase. Like RPB10, it is essential for yeast cell viability. RPB12 is also a zinc-binding protein with a canonical tetra-coordinating zinc motif but binds zinc in vitro much less efficiently than the RPB10 subunit. It has been shown to interact with both RPB1 and RPB2 in vitro and the human subunit can functionally substitute for its yeast counterpart.
RPB12/RPC10 (RNA polymerase II subunit K) is required for growth in Saccharomyces cerevisiae. The carboxy-terminal domain (CTD) of RNAP II plays a major role in recruiting many of these activities to the transcriptional machinery.
Physical form【外形】
Clear and colorless frozen liquid solution
Preparation Note【制备说明】
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. While working, please keep sample on ice.
产品性质
biological source【生物来源】
human
recombinant【重组】
expressed in E. coli
Assay【测定】
≥80% (SDS-PAGE)
form【形式】
frozen liquid
mol wt【分子量】
~33 kDa
packaging【包装】
pkg of 10 μg
storage condition【储存条件】
avoid repeated freeze/thaw cycles
concentration【浓度】
100 μg/mL
color【颜色】
clear colorless
NCBI accession no.【NCBI登记号】
NM_005034
UniProt accession no.【UniProt登记号】
P53803
shipped in【运输】
dry ice
storage temp.【储存温度】
−70℃
Gene Information
human ... POLR2K(5440)
安全信息
Storage Class Code【储存分类代码】
10 - Combustible liquids
WGK
WGK 1
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