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PRMT4 peptide, biotin

产品编号:4139945
规格:≥90% (HPLC)
包装规格:80 NMOL
产品类别:进口试剂
品牌:Sigma-Aldrich
优惠价:立即咨询
产品价格
产品编号包装单位单价(元)国内现货国外库存询价单
413994580 NMOL4280
基本信息
NACRES
NA.32
General description【一般描述】
Protein arginine methyltransferase 4 (PRMT4), which is also known as coactivator associated arginine methyltransferase 1 (CARM1), is part of the protein arginine methyltransferase (PRMT) family. The gene encoding this protein is localized on human chromosome 19p13.2.
Application【应用】
Study enzyme kinetics, and screen small molecular inhibitors of PRMT4 histone methyltransferase for drug discovery and HTS applications.
Biochem/physiol Actions【生化/生理作用】
Protein arginine methyltransferase 4 (PRMT4) methylates arginine residues of histones and other proteins and thus has a role in modulation of gene expression. The protein also methylates histone acetyl transferases. It has been shown to associate with Mi2a, a chromatin remodeler. It also associates with nuclear factor-κB (NF-κB), estrogen receptor and tumor suppressor p53 and is recruited to specific target genes. PRMT4 has a role in pre-mRNA splicing and DNA damage response. The protein has been shown to be upregulated in liver, prostate and breast cancers.
Physical form【外形】
Supplied in a TRIS-buffered solution.
Other Notes【其他说明】
200 μL at 400 μM, or 80 nmol. Sold as 80 nmol
产品性质
Assay【测定】
≥90% (HPLC)
form【形式】
aqueous solution
packaging【包装】
pkg of 80 nmol
concentration【浓度】
400 μM
UniProt accession no.【UniProt登记号】
Q86X55
shipped in【运输】
dry ice
storage temp.【储存温度】
−70℃
Gene Information
human ... CARM1(10498)
安全信息
Storage Class Code【储存分类代码】
12 - Non Combustible Liquids
WGK
WGK 2
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