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Porcine Pulmonary Artery Endothelial Cells: PPAEC (Cryovial)
基本信息
| NACRES | NA.81 |
| General description【一般描述】 | PPAEC have been used in a pioneer study of endothelial cell motility, where it was determined that asymmetric dimethylarginine (ADMA), an inhibitor of nitric oxide production and a cardiovascular risk factor, decreased PKG-mediated phosphorylation of VASP, leading to downregulation of Rac1 and induction of stress fibers and focal adhesions via RhoA/ROCK dependent mechanism, leading to decreased cell motility, and increase in endothelial permeability, thus linking vascular repair and function with NO production (Wojciak-Stothard, 2007, 2009). PPAEC were also used to assess endothelial adhesion to decellularized porcine arteries in order to develop grafts for human vascular repair (Xiong, 2013). |
| Cell Line Origin【细胞系来源】 | Artery |
| Application【应用】 | cardiovascular function, screening of drug candidates, angiogenesis, vasodilator function, transport of deoxygenated bloood from heart to lungs |
| Components【组分】 | Porcine Endothelial Cell Growth Medium that contains 10% FBS and 10% DMSO |
| Preparation Note【制备说明】 |
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| Subculture Routine【传代培养常规】 | Please refer to the PPAEC Culture Protocol. |
产品性质
| biological source【生物来源】 | Porcine pulmonary artery (Normal healthy) |
| Quality Level【质量水平】 | 100 |
| form【形式】 | solid |
| packaging【包装】 | pkg of 500,000 cells |
| growth mode【生长模式】 | Adherent |
| karyotype【核型】 | 2n = 38 |
| morphology【形态学】 | Endothelial |
| technique(s) | cell culture | mammalian: suitable |
| relevant disease(s)【相关疾病】 | diabetes; cardiovascular diseases |
| shipped in【运输】 | dry ice |
| storage temp.【储存温度】 | −196℃ |
安全信息
| Storage Class Code【储存分类代码】 | 13 - Non Combustible Solids |
| WGK | WGK 3 |
