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Monoclonal Anti-ERp57-Atto 488 antibody produced in mouse

产品编号:4137870
规格:clone 4F9, affinity isolated antibody, buffered aqueous solution
包装规格:100 μG
产品类别:进口试剂
品牌:Sigma-Aldrich
优惠价:立即咨询
产品价格
产品编号包装单位单价(元)国内现货国外库存询价单
4137870100 μG3380
产品别名

Monoclonal Anti-ERp57-Atto 488 antibody produced in mouse

Anti-PDIA3

基本信息
NACRES
NA.45
Immunogen【免疫原】
Immunogen Region: Other – provide in Additional Product Details
Immunogen Description: Human recombinant ERp57 (Grp58) protein corresponding to amino acids 25 - 505 (his-tagged)
Immunogen Species: Human
Immunogen type: Recombinant protein
Application【应用】

Western blotting
Dilution 1:1000
Tissue/Cell Type Used: HeLa cell lysate

Immunofluorescence
Dilution 1:100
Tissue/Cell Type Used: HeLa
Physical form【外形】
50% glycerol, 0.09% Sodium Azide
PBS pH 7.4
Preparation Note【制备说明】
Derived from cell/tissue culture
Other Notes【其他说明】
Additional Product Details:
Immunogen region: Amino acids 25-505
Lot Expiration/Retest Date: Expires 1 year from purchase
Target/Gene Description: ERp57, also known as Glucose Regulated Protein 58 (Grp58), Hormone-Induced Protein-70 (HIP-70) and microsomal Carnitine Palmitoyltransferase, is a member of the protein disulfide isomerase family, containing two canonical CXHC tetrapeptide active site motifs (1-5). It has quite a few diverse roles. It functions as an accessory oxidoreductase involved in disulfide bond formation. In the ER, ERp57 interacts with membrane bound calnexin and soluble calreticulin (lectin chaperones) via their praline rich P-domain arms. Lectin chaperones bind nascent non-native glycoproteins, and position ERp57 to act upon the immature or misfolded glycoproteins that possess mono-glycosylated side chains. ERp57 deletion impairs posttranslational phases of influenza hema-glutinin folding, and causes accelerated release of MHC-I molecules, resulting in the coupling of sub-optimal peptides and reduced expression and stability on the cell surface . ERp57 also contains two thioredoxin active-site sequences, CGHC and an estrogen-binding domain. ERp57 is induced by both estrogen and leuteinizing-hormone-releasing hormone in the hippocampus .
Purification method: Protein G purified
Product type: Primary antibody
Antibody structure: Whole Antibody
Protein ID: NP_005304.3
产品性质
biological source【生物来源】
mouse
conjugate【偶联物】
Atto 488 conjugate
antibody form【抗体形式】
affinity isolated antibody
antibody product type
primary antibodies
clone【克隆】
4F9
monoclonal
description【描述】
clone 4F9, purified immunoglobulin, buffered aqueous solution
form【形式】
buffered aqueous solution
species reactivity
human (Tested)
packaging【包装】
pkg of 100 μg
storage condition【储存条件】
avoid repeated freeze/thaw cycles
protect from light
concentration【浓度】
1.0 mg/mL
target molecular weight【靶分子量】
57 kDa
technique(s)
immunofluorescence: 1:100
western blot: 1:1000
isotype【同位素/亚型】
IgG2b
UniProt accession no.【UniProt登记号】
P30101
shipped in【运输】
wet ice
storage temp.【储存温度】
−20℃
Gene Information
human ... PDIA3(2923)
产品说明
Storage and Stability【储存及稳定性】
Protect from light; avoid repeated freeze-thaw cycles. Store at -20 ℃ long-term, 2-8 ℃ short-term.
Disclaimer【免责声明】
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
安全信息
Storage Class Code【储存分类代码】
10 - Combustible liquids
WGK
WGK 2
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