CD5 human

NA.32

CD5 (cluster of differentiation 5) is a lymphocyte surface receptor. It is expressed by all T cells and the B1a subset of mature B cells (participating in the generation of low-affinity polyreactive antibodies). The CD5 gene is mapped to human chromosome 11q12.
Recombinant human CD5 protein, fused to His-tag at N-terminus, was expressed in Escherichia coli.

CD5 (cluster of differentiation 5) is required for fine tuning of TCR (T-cell receptor) signaling. It also controls activation-mediated T cell death and recognizes pathogen-associated molecular patterns. In T and B1 cells, CD5 negatively regulates the signaling by clonotypic antigen-specific receptor. CD5 is present in patients with rheumatoid arthritis, systemic lupus erythematosus, Sjögren syndrome, Grave′s Basedow thyroiditis and type 1 diabetes mellitus. In infants, high levels of CD5⁺ cells suggest the risk of development of allergic disease. The gene is also associated with peripheral T-cell lymphoma and mature B-cell neoplasms (mainly chronic lymphocytic leukemia and mantle cell lymphoma).

1 mg/mL in 20 mM Tris-HCl buffer (pH 8.0) containing 0.4 M Urea and 10% glycerol.

human

expressed in E. coli

≥80% (SDS-PAGE)

liquid

41 kDa (371 aa, 25-372 aa + His tag)

pkg of 50 μg

1 mg/mL

<1 EU/μg endotoxin (LAL test)

P06127

dry ice

−70℃

human ... CD5(921)

13 - Non Combustible Solids

WGK 3