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BRD3 (24-144) GST tag human

产品编号:4116931
规格:recombinant, expressed in E. coli, ≥95% (SDS-PAGE)
包装规格:20 μG,100 μG
产品类别:进口试剂
品牌:Sigma-Aldrich
优惠价:立即咨询
产品价格
产品编号包装单位单价(元)国内现货国外库存询价单
411693120 μG3480
4116931100 μG11860
产品别名

BRD3 (24-144) GST tag human

RING3L

Bromodomain containing protein 3

ORFX

RING3-like protein

产品性质
biological source【生物来源】
human
recombinant【重组】
expressed in E. coli
Assay【测定】
≥95% (SDS-PAGE)
form【形式】
liquid
mol wt【分子量】
41.2 kDa (24-144 aa + NT GST Tag)
packaging【包装】
pkg of 100 μg
pkg of 20 μg
NCBI accession no.【NCBI登记号】
NM_007371
UniProt accession no.【UniProt登记号】
Q15059
shipped in【运输】
dry ice
storage temp.【储存温度】
−70℃
Gene Information
human ... BRD3(8019)
基本信息
General description【一般描述】
The acetylation of histone lysine residues plays a crucial role in the epigenetic regulation of gene transcription. A bromodomain is a protein domain that recognizes acetylated lysine residues such as those on the N-terminal tails of histones. This recognition is often a prerequisite for protein-histone association and chromatin remodeling. These domains function in the linking of protein complexes to acetylated nucleosomes, thereby controlling chromatin structure and gene expression. Thus, bromodomains serve as “readers” of histone acetylation marks regulating the transcription of target promoters. The BET family of proteins, defined by tandem Bromodomains and an Extra Terminal domain, include BRD2, BRD3, BRD4, and BRDT. The BET proteins play a key role in many cellular processes, including inflammatory gene expression, mitosis, and viral/host interactions. The isolated individual or tandem bromodomains of BRD3 have been shown to bind acetylated histone tails, serving to couple histone acetylation marks to the transcriptional regulation of target promoters. Small molecule inhibitors of these interactions hold promise as useful therapeutics for human disease.
Physical form【外形】
50 mM Tris, pH 7.5, containing 500 mM sodium chloride, 5% glycerol, and 5 mM β-mercaptoethanol.
安全信息
Pictograms【象形图】
GHS07
Signal word【警示用语:】
Warning
Hazard Statements
H317 - H319 - H412
Precautionary Statements
P273 - P280 - P305 + P351 + P338 - P333 + P313 - P337 + P313
Hazard Classifications【危险分类】
Aquatic Chronic 3 - Eye Irrit. 2 - Skin Sens. 1
Storage Class Code【储存分类代码】
13 - Non Combustible Solids
WGK
WGK 3
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