您的位置:首页 > 产品中心 > BRD3 (24-144) GST tag human
BRD3 (24-144) GST tag human
产品编号: | 4116931 |
规格: | recombinant, expressed in E. coli, ≥95% (SDS-PAGE) |
包装规格: | 20 μG,100 μG |
产品类别: | 进口试剂 |
品牌: | Sigma-Aldrich |
优惠价: | 立即咨询 |
产品别名
BRD3 (24-144) GST tag human
RING3L
Bromodomain containing protein 3
ORFX
RING3-like protein
产品性质
biological source【生物来源】 | human |
recombinant【重组】 | expressed in E. coli |
Assay【测定】 | ≥95% (SDS-PAGE) |
form【形式】 | liquid |
mol wt【分子量】 | 41.2 kDa (24-144 aa + NT GST Tag) |
packaging【包装】 | pkg of 100 μg pkg of 20 μg |
NCBI accession no.【NCBI登记号】 | NM_007371 |
UniProt accession no.【UniProt登记号】 | Q15059 |
shipped in【运输】 | dry ice |
storage temp.【储存温度】 | −70℃ |
Gene Information | human ... BRD3(8019) |
基本信息
General description【一般描述】 | The acetylation of histone lysine residues plays a crucial role in the epigenetic regulation of gene transcription. A bromodomain is a protein domain that recognizes acetylated lysine residues such as those on the N-terminal tails of histones. This recognition is often a prerequisite for protein-histone association and chromatin remodeling. These domains function in the linking of protein complexes to acetylated nucleosomes, thereby controlling chromatin structure and gene expression. Thus, bromodomains serve as “readers” of histone acetylation marks regulating the transcription of target promoters. The BET family of proteins, defined by tandem Bromodomains and an Extra Terminal domain, include BRD2, BRD3, BRD4, and BRDT. The BET proteins play a key role in many cellular processes, including inflammatory gene expression, mitosis, and viral/host interactions. The isolated individual or tandem bromodomains of BRD3 have been shown to bind acetylated histone tails, serving to couple histone acetylation marks to the transcriptional regulation of target promoters. Small molecule inhibitors of these interactions hold promise as useful therapeutics for human disease. |
Physical form【外形】 | 50 mM Tris, pH 7.5, containing 500 mM sodium chloride, 5% glycerol, and 5 mM β-mercaptoethanol. |
安全信息
Pictograms【象形图】 | GHS07 |
Signal word【警示用语:】 | Warning |
Hazard Statements | H317 - H319 - H412 |
Precautionary Statements | P273 - P280 - P305 + P351 + P338 - P333 + P313 - P337 + P313 |
Hazard Classifications【危险分类】 | Aquatic Chronic 3 - Eye Irrit. 2 - Skin Sens. 1 |
Storage Class Code【储存分类代码】 | 13 - Non Combustible Solids |
WGK | WGK 3 |