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BIO 1211 trifluoroacetate salt

产品编号:4116778
规格:≥97% (HPLC)
CAS NO:187735-94-0
包装规格:1 MG
产品类别:进口试剂
品牌:Sigma-Aldrich
优惠价:立即咨询
产品价格
产品编号包装单位单价(元)国内现货国外库存询价单
41167781 MG1800
产品别名

187735-94-0

BIO 1211 trifluoroacetate salt

N-[2-[4-[[[(2-Methylphenyl)amino]carbonyl]amino]phenyl]acetyl]-L-leucyl-L-α-aspartyl-L-valyl-L-proline trifluoroacetate

N-[[4-[[[(2-Methylphenyl)amino]carbonyl]amino]-phenyl]acetyl]-Leu-Asp-Val-Pro trifluoroacetate

BIO1211 trifluoroacetate

2-MPUPA-LDVP trifluoroacetate

N-[[4-[[[(2-Methylphenyl)amino]carbonyl]amino]-phenyl]acetyl]-LDVP trifluoroacetate

4-(N′-(2-Methylphenyl)urea)-phenylacetyl-LDVP trifluoroacetate

N-[[4-[[[(2-Methylphenyl)amino]carbonyl]amino]-phenyl]acetyl]-fibronectin CS-1 fragment (1980-1983) trifluoroacetate

BIO-1211 trifluoroacetate

结构式
基本信息
Empirical Formula【经验(实验)分子式】
C36H48N6O9 · xC2HF3O2
Molecular weight
708.80 (free base basis)
MDL number
MFCD02259692
Biochem/physiol Actions【生化/生理作用】
BIO 1211 is a selective, tight-binding α4β1 (VLA-4, very late antigen-4; koff = 1.4 x 10-4/s, KD = 70 pM) integrin antagonist (VCAM-Ig Jurkat surface binding IC50 = 1 nM; integrin-mediated cell adhesion IC50 = 4 nM/α4β1, 2 μM/α4β7, >100 μM/α1β1, α5β1, α6β1, αLβ2, αIIBβ3) based on the Leu-Asp-Val (LDV) sequence from the alternatively spliced connecting segment-1 (CS-1) of fibronectin (aa 1980-1983). In addition to probing α4β1-mediated cellular responses, BIO 1211 is also widely used in animal disease models in vivo, including MS (5-10 mg/kg; murine EAE) and asthma (1-10 mg/kg via intranasal or nebulizer to mice, rats, sheep; 3 mg/sheep iv.).
产品性质
Assay【测定】
≥97% (HPLC)
form【形式】
film
lyophilized powder
storage condition【储存条件】
desiccated
color【颜色】
white to beige
shipped in【运输】
wet ice
storage temp.【储存温度】
−20℃
安全信息
Storage Class Code【储存分类代码】
13 - Non Combustible Solids
WGK
WGK 3
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