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比卡鲁胺 (CDX)

Bicalutamide
产品编号:4116775
规格:United States Pharmacopeia (USP) Reference Standard
CAS NO:90357-06-5
包装规格:200 MG
产品类别:进口试剂
品牌:USP
优惠价:立即咨询
产品编号包装单位单价(元)国内现货国外库存询价单
4116775200 MG3230
产品别名

90357-06-5

比卡鲁胺 (CDX)

Bicalutamide

Cosudex

Casodex

Bicalutamide (CDX)

N-[4-Cyano-3-(trifluoromethyl)phenyl]-3-[(4-fluorophenyl)sulfonyl]-2-hydroxy-2-methylpropanamide

比卡胺

比卡他胺

N-[4-氰基-3-(三氟甲基)苯基]-3-(4-氟苯硫酰基)-2-甲基-2-羟基丙酰胺

结构式
基本信息
Empirical Formula【经验(实验)分子式】
C18H14F4N2O4S
Molecular weight
430.37
MDL number
MFCD00869971
PubChem Substance ID【PubChem化学物质编号】
329749112
NACRES
NA.24
General description【一般描述】
This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.
For further information and support please go to the website of the issuing Pharmacopoeia.
Biochem/physiol Actions【生化/生理作用】
比卡鲁胺 (CDX) 是一种非杀菌的雄激素受体 (AR) 拮抗剂,是纯抗雄激素。它通过平衡组蛋白乙酰化/去乙酰化和共调剂募集发挥作用。比卡鲁胺(CDX)消除了雄激素介导的表达。例如,前列腺癌、PLZF(早幼粒细胞白血病锌指蛋白)和GADD45γ中的MMP13上调(生长停滞和可诱导的DNA损伤,γ)。通过雄激素,对PI3K /AKT磷酸化进行非基因组、非转录依赖性刺激,抑制比卡鲁胺(CDX)。
Analysis Note【分析说明】
These products are for test and assay use only. They are not meant for administration to humans or animals and cannot be used to diagnose, treat, or cure diseases of any kind.  ​
Other Notes【其他说明】
Sales restrictions may apply.
产品性质
grade【等级】
pharmaceutical primary standard
manufacturer/tradename
USP
application(s)
pharmaceutical (small molecule)
format【格式】
neat
storage temp.【储存温度】
2-8℃
SMILES string
CC(O)(CS(=O)(=O)c1ccc(F)cc1)C(=O)Nc2ccc(C#N)c(c2)C(F)(F)F
InChI
1S/C18H14F4N2O4S/c1-17(26,10-29(27,28)14-6-3-12(19)4-7-14)16(25)24-13-5-2-11(9-23)15(8-13)18(20,21)22/h2-8,26H,10H2,1H3,(H,24,25)
InChI key
LKJPYSCBVHEWIU-UHFFFAOYSA-N
Gene Information
human ... AR(367)
安全信息
Pictograms【象形图】
GHS08,GHS09
Signal word【警示用语:】
Danger
Hazard Statements
H351 - H360FD - H410
Precautionary Statements
P202 - P273 - P280 - P308 + P313 - P391 - P405
Hazard Classifications【危险分类】
Aquatic Chronic 1 - Carc. 2 - Repr. 1B
Storage Class Code【储存分类代码】
6.1C - Combustible, acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
WGK
WGK 3
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