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Ataxin3 active human
| 产品编号： | 4116543 |
| 规格： | recombinant, expressed in E. coli, ≥59% (SDS-PAGE) |
| 包装规格： | 250 μG |
| 产品类别： | 进口试剂 |
| 品牌： | Sigma-Aldrich |
| 优惠价： | 立即咨询 |
产品别名
Ataxin3 active human
ATX3
MJD
AT3
JOS
SCA3
基本信息
| NACRES | NA.32 |
| General description【一般描述】 | Ataxin3 (ATXN3) is encoded by the gene mapped to human chromosome 14q32. The encoded protein is characterized with a ubiquitin interaction motif (UIM) domain involved in binding mono and/or polyubiquitylated proteins. |
| Application【应用】 | Useful for the study of enzyme kinetics, screening inhibitors, and selectivity profiling. |
| Biochem/physiol Actions【生化/生理作用】 | Ataxin3 (ATXN3) is a polyglutamine neurodegenerative disease protein involved in the ubiquitin-proteasome pathway. ATXN3 performs all the functions same as ubiquitin proteases such as, reducing polyubiquitylation of 125I-lysozyme by removing ubiquitin from polyubiquitin chains, cleaving a ubiquitin protease substrate and binding the specific ubiquitin protease inhibitor, ubiquitin-aldehyde. Mutation in the gene has been observed in spinocerebellar ataxia type 3 patients. |
产品性质
| biological source【生物来源】 | human |
| recombinant【重组】 | expressed in E. coli |
| Assay【测定】 | ≥59% (SDS-PAGE) |
| form【形式】 | aqueous solution |
| mol wt【分子量】 | 42 kDa |
| packaging【包装】 | pkg of 250 μg |
| NCBI accession no.【NCBI登记号】 | NM_004993 |
| UniProt accession no.【UniProt登记号】 | P54252 |
| shipped in【运输】 | dry ice |
| storage temp.【储存温度】 | −70℃ |
| Gene Information | human ... ATXN3(4287) |
安全信息
| Pictograms【象形图】 | GHS07,GHS08 |
| Signal word【警示用语：】 | Danger |
| Hazard Statements | H315 - H319 - H360D |
| Precautionary Statements | P202 - P264 - P280 - P302 + P352 - P305 + P351 + P338 - P308 + P313 |
| Hazard Classifications【危险分类】 | Eye Irrit. 2 - Repr. 1B - Skin Irrit. 2 |
| Storage Class Code【储存分类代码】 | 6.1D - Non-combustible, acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects |
| WGK | WGK 1 |
