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Anti-Ubiquilin 2 Antibody, clone 6H9
产品别名
Anti-Ubiquilin 2 Antibody, clone 6H9
Ubiquilin-2, Chap1, DSK2 homolog, Protein linking IAP with cytoskeleton 2, PLIC-2, hPLIC-2, Ubiquitin-like product Chap1/Dsk2
基本信息
eCl@ss | 32160702 |
NACRES | NA.41 |
General description【一般描述】 | Ubiquilin-2, also known as Chap1, DSK2 homolog, Protein linking IAP with cytoskeleton 2 (PLIC-2 or hPLIC-2), Ubiquitin-like product Chap1/Dsk2, and encoded by the gene UBQLN2/N4BP4/PLIC2, is a protein that appears to modulate the half-life of proteins destined to be degraded by the proteasome. Ubiquilin 2 binds UBE3A and BTRC ubquitin ligases and interacts with the 19S proteasome subunit to mediate its activity. Ubiquilin 2 is localized to the cytoplasm and nucleus, and colocalizes with proteasome. Ubiquilin 2 is expressed in mitotic cells very strongly; expression is low in non-dividing cells. Defects in Ubiquilin 2 may be associated with ALS form 15 a neurodegenerative disorder affecting upper motor neurons in the brain and lower motor neurons in the brain stem and spinal cord, resulting in fatal paralysis. |
Immunogen【免疫原】 | Recombinant protein corresponding to human Ubiquilin 2. |
Application【应用】 | Western Blotting Analysis: 1.0 µg/mL from a representative lot detected Ubiquilin 2 in 10 µg of SH-SY5Y and NIH-3T3 cell lysate. Immunocytochemistry Analysis: A representative lot detected Ubiquilin 2 in HeLa cells. Detect Ubiquilin-2 using this mouse monoclonal antibody, Anti-Ubiquilin 2 Antibody, clone 6H9 validated for use in western blotting & ICC. Research Category Neuroscience Research Sub Category Developmental Signaling |
Quality【质量】 | Evaluated by Western Blotting in U-251 cell lysate. Western Blotting Analysis: 1.0 µg/mL of this antibody detected Ubiquilin 2 in 10 µg of U-251 cell lysate. |
Physical form【外形】 | Format: Purified Purified mouse monoclonal IgG1κ in buffer containing PBS, 50% glycerol, and 0.05% sodium azide. Protein G Purified |
Other Notes【其他说明】 | Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration. |
产品性质
Quality Level【质量水平】 | 100 |
biological source【生物来源】 | mouse |
antibody form【抗体形式】 | purified immunoglobulin |
antibody product type | primary antibodies |
clone【克隆】 | 6H9, monoclonal |
species reactivity | mouse, human |
technique(s) | immunocytochemistry: suitable western blot: suitable |
isotype【同位素/亚型】 | IgG1κ |
NCBI accession no.【NCBI登记号】 | NP_038472 |
UniProt accession no.【UniProt登记号】 | Q9UHD9 |
shipped in【运输】 | wet ice |
Gene Information | human ... UBQLN2(29978) |
产品说明
Target description【目标描述】 | ~66 kDa observed |
Storage and Stability【储存及稳定性】 | Stable for 1 year at -20°C from date of receipt. |
Disclaimer【免责声明】 | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
安全信息
Storage Class Code【储存分类代码】 | 10 - Combustible liquids |
WGK | WGK 2 |