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Anti-Tryptophan Hydroxylase antibody, Mouse monoclonal

产品编号:4115631
规格:clone WH-3, purified from hybridoma cell culture
包装规格:100 μL
产品类别:进口试剂
品牌:Sigma-Aldrich
优惠价:立即咨询
产品价格
产品编号包装单位单价(元)国内现货国外库存询价单
4115631100 μL6730
产品别名

Anti-Tryptophan Hydroxylase antibody, Mouse monoclonal

Anti-TPH

Anti-TpOH

产品性质
Quality Level【质量水平】
200
biological source【生物来源】
mouse
antibody form【抗体形式】
purified from hybridoma cell culture
antibody product type
primary antibodies
clone【克隆】
WH-3, monoclonal
form【形式】
buffered aqueous solution
mol wt【分子量】
antigen ~55 kDa
species reactivity
human, rat, mouse, rabbit, sheep
concentration【浓度】
~1.0 mg/mL
technique(s)
immunoblotting: 2-4 μg/mL using rabbit pineal gland lysate
immunofluorescence: suitable
immunohistochemistry: suitable
isotype【同位素/亚型】
IgG3
shipped in【运输】
dry ice
storage temp.【储存温度】
−20℃
基本信息
General description【一般描述】
Anti-Tryptophan Hydroxylase antibody, Mouse monoclonal (mouse IgG3 isotype) is derived from the WH-3 hybridoma produced by the fusion of mouse myeloma cells and splenocytes from a BALB/c mouse immunized with recombinant rabbit Tryptophan Hydroxylase. Tryptophan Hydroxylase (TPH), also known as TpOH, TrpH or L-tryptophan tetrahydropteridine: oxygen oxidoreductase (EC 1.14.16.4) is a member of biopterin-dependent aromatic amino acid hydroxylases family, together with tyrosine hydroxylase and phenylalanine hydroxylase. This gene spanning 29kbp with 11 exons is mapped to human chromosome 11p15.3-p14. This 444 amino acid protein is expressed in the gut, spleen, thymus and also in the pineal gland and the pituitary.
Immunogen【免疫原】
recombinant rabbit Tryptophan Hydroxylase.
Application【应用】
Anti-Tryptophan Hydroxylase antibody, Mouse monoclonal has been used in:
  • immunoblotting
  • immunohistochemistry
  • immunofluorescence

Biochem/physiol Actions【生化/生理作用】
Tryptophan Hydroxylase (TPH) is a rate-limiting tetramer enzyme in the synthetic pathway of neurotransmitter serotonin from L-tryptophan and is considered a key factor for the maintenance of normal serotonin transmission in the central nervous system. The tryptophan hydroxylase 1 gene (TPH1) catalyzes the synthesis of 5-hydroxytryptophan. Mutation in the TPH1 gene leads to schizophrenia, irritable bowel syndrome (IBS) in women, suicidal behavior and depressive disorders.The encoded protein plays a vital role in regulation of cardiovascular function.
Physical form【外形】
Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.
产品说明
Disclaimer【免责声明】
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
安全信息
Storage Class Code【储存分类代码】
12 - Non Combustible Liquids
WGK
WGK 1
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