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Anti-Tropomyosin Antibody, clone 15D12.2

产品编号:4115596
规格:clone 15D12.2, from mouse
包装规格:100 μG
产品类别:进口试剂
品牌:Sigma-Aldrich
优惠价:立即咨询
产品价格
产品编号包装单位单价(元)国内现货国外库存询价单
4115596100 μG5850
产品别名

Anti-Tropomyosin Antibody, clone 15D12.2

tropomyosin 1 (alpha), cardiomyopathy, hypertrophic 3, tropomyosin 1 alpha chain, HTM-alpha, Alpha-tropomyosin, chromosome 15 open reading frame 13, Tropomyosin-1, sarcomeric tropomyosin kappa, alpha tropomyosin

基本信息
eCl@ss
32160702
NACRES
NA.41
General description【一般描述】
Tropomyosins (Tms) are a family of >40 highly conserved protein isoforms resulting from alternative splicing of four different genes during development and that are expressed in numerous cell types. These proteins form coiled-coil heterodimers which bind to actin polymers along the α-helical grove. Tropomyosin’s function varies depending on cell type in which it is expressed. Within muscle, Tms play a role in the regulation of actin-myosin interplay for the purpose of mediating muscle contraction. In non-muscle cells, studies suggest a role in the stabilization of actin filaments, along with protecting actin filaments from the severing action of gelsolin and ADF/cofilin depolymerization. Tms also appear to have a role in the moderation of access to actin for other actin-binding proteins. Tropomyosin has an integral role in maintaining cardiovascular homeostasis. Down-regulation of Tms expression has been observed in tumor cells indicating a possible role for Tms as tumor suppressors.
Specificity【特异性】
The antibody recognizes the entire exon 9d of Tropomyosin.
Immunogen【免疫原】
Linear peptide corresponding to the entire exon 9d of rat Tropomyosin.
Epitope: Exon 9d
Application【应用】
Research Sub Category
Cytoskeleton

Muscle Physiology
Research Category
Cell Structure

Metabolism
Detect Tropomyosin using this Anti-Tropomyosin Antibody, clone 15D12.2 validated for use in WB, IH.
Immunohistochemistry Analysis: 1:300 dilution from a representative lot detected Tropomyosin in human striated muscle tissue.
Quality【质量】
Evaluated by Western Blot in mouse brain tissue lysate.

Western Blot Analysis: 0.5 µg/mL of the antibody detected Tropomyosin in 10 µg of mouse brain tissue lysate.
Physical form【外形】
Purified mouse monoclonal IgG2bκ in buffer containing 0.1 M Tris-Glycine, pH 7.4, 150 mM NaCl with 0.05% sodium azide.
Format: Purified
Protein G
Analysis Note【分析说明】
Control
Mouse brain tissue lysate
Other Notes【其他说明】
Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.
产品性质
Quality Level【质量水平】
100
biological source【生物来源】
mouse
antibody form【抗体形式】
purified antibody
antibody product type
primary antibodies
clone【克隆】
15D12.2, monoclonal
species reactivity
human, mouse
species reactivity (predicted by homology)
rat (based on 100% sequence homology)
technique(s)
immunohistochemistry: suitable
western blot: suitable
isotype【同位素/亚型】
IgG2bκ
NCBI accession no.【NCBI登记号】
NP_001029243
UniProt accession no.【UniProt登记号】
Q923Z2
shipped in【运输】
wet ice
产品说明
Target description【目标描述】
~ 30-40 kDa observed MWs. Tm6: 40 kDa; Tm1: 38 kDa; Tm2: 36 kDa; Tm3: 34 kDa; Tm5: 30 kDa
Storage and Stability【储存及稳定性】
Stable for 1 year at 2-8°C from date of receipt.
Disclaimer【免责声明】
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
安全信息
Storage Class Code【储存分类代码】
12 - Non Combustible Liquids
WGK
WGK 1
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