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Anti-Spred-1 Antibody, clone M23-P2G3
| 产品编号： | 4114716 |
| 规格： | clone M23-P2G3, from mouse, purified by affinity chromatography |
| 包装规格： | 100 μG |
| 产品类别： | 进口试剂 |
| 品牌： | Sigma-Aldrich |
| 优惠价： | 立即咨询 |
产品别名
Anti-Spred-1 Antibody, clone M23-P2G3
Sprouty-related, EVH1 domain-containing protein 1, Spred-1, hSpred1
基本信息
| eCl@ss | 32160702 |
| NACRES | NA.41 |
| General description【一般描述】 | Sprouty-related, EVH1 domain-containing protein 1 (SPRED1) is a tyrosine kinase substrate which has a cysteine-rich domain which resembles the SPR domain at the carboxy terminus. SPRED1 associated with Ras blocks phosphorylation of Raf and disrupts MAP kinase signaling during the differentiation of neuronal cells and myocytes. A mutation in SPRED1 has been linked to Lugius syndrome, an autosomal dominant RAS-MAPK pathway syndrome. |
| Immunogen【免疫原】 | Linear peptide corresponding to human Spred-1. |
| Application【应用】 | Immunocytochemistry Analysis: A representative lot detected Spred-1 in HeLa cells. Research Category Neuroscience Detect Spred-1 using this mouse monoclonal antibody, Anti-Spred-1 Antibody, clone M23-P2G3 validated for use in western blotting & ICC. Research Sub Category Developmental Signaling |
| Quality【质量】 | Evaluated by Western Blotting in mouse brain tissue lysate. Western Blotting Analysis: 1.0 µg/mL of this antibody detected Spred-1 in 10 µg of mouse brain tissue lysate. |
| Physical form【外形】 | Protein G Purified Purified mouse monoclonal IgG1λ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide. |
| Other Notes【其他说明】 | Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration. |
产品性质
| Quality Level【质量水平】 | 100 |
| biological source【生物来源】 | mouse |
| antibody form【抗体形式】 | purified antibody |
| antibody product type | primary antibodies |
| clone【克隆】 | M23-P2G3, monoclonal |
| purified by【纯化方式】 | affinity chromatography |
| species reactivity | rat, mouse |
| species reactivity (predicted by homology) | human (based on 100% sequence homology) |
| technique(s) | immunocytochemistry: suitable western blot: suitable |
| isotype【同位素/亚型】 | IgG1λ |
| NCBI accession no.【NCBI登记号】 | NP_689807 |
| UniProt accession no.【UniProt登记号】 | Q7Z699 |
| shipped in【运输】 | wet ice |
| Gene Information | human ... SPRED1(161742) |
产品说明
| Target description【目标描述】 | ~ 60 kDa observed |
| Storage and Stability【储存及稳定性】 | Stable for 1 year at 2-8°C from date of receipt. |
| Disclaimer【免责声明】 | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
安全信息
| Storage Class Code【储存分类代码】 | 12 - Non Combustible Liquids |
| WGK | WGK 1 |
