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Anti-Sox11 Antibody
| 产品编号： | 4114624 |
| 规格： | from rabbit, purified by affinity chromatography |
| 包装规格： | 100 μG |
| 产品类别： | 进口试剂 |
| 品牌： | Sigma-Aldrich |
| 优惠价： | 立即咨询 |
产品别名
Anti-Sox11 Antibody
Transcription factor SOX-11
基本信息
| eCl@ss | 32160702 |
| NACRES | NA.41 |
| General description【一般描述】 | SRY box-containing 11 (Sox11) is a neural transcription factor belonging to the DNA-binding high-mobility group (HMG) box protein super family. It is highly expressed during embryonic development and regulates genes involved in neurite growth and survival. Sox11 plays an important role in the formation of sensory neurons and organogenesis. Sox11-deficient mice show defects in multiple organs including the lung, heart, and pancreas. Sox11 also plays a critical role as a tumor suppressor. Epigenetic suppression of the Sox11 gene, primarily through promoter hypermethylation, contributes to various forms of neoplasms. In adults, Sox11 may be involved in the regeneration of neurons after nerve injury by inducing the expression of the small proline rich protein 1a gene (Sprr1a). |
| Immunogen【免疫原】 | KLH-conjugated linear peptide corresponding to human Sox-11. |
| Application【应用】 | Immunohistochemistry: A 1:1,000 dilution from a representative lot detected Sox-11 in normal mouse hippocampus and cerebellum tissues. Western Blot Analysis: A representative lot detecte Sox-11 in human brain tissue lysate. Research Category Neuroscience Research Sub Category Developmental Neuroscience Anti-Sox11 Antibody detects level of Sox11 & has been published & validated for use in 0. |
| Quality【质量】 | Evaluated by Western Blot in mouse brain tissue lysate. Western Blot Analysis: 0.5 mg/mL of this antibody detected Sox-11 in 10 mg of mouse brain tissue lysate. |
| Physical form【外形】 | Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide. Affinity purified |
| Analysis Note【分析说明】 | Control Mouse brain tissue lysate |
| Other Notes【其他说明】 | Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration. |
产品性质
| biological source【生物来源】 | rabbit |
| Quality Level【质量水平】 | 100 |
| antibody form【抗体形式】 | affinity isolated antibody |
| antibody product type | primary antibodies |
| clone【克隆】 | polyclonal |
| purified by【纯化方式】 | affinity chromatography |
| species reactivity | human, mouse |
| technique(s) | immunohistochemistry: suitable (tissue) western blot: suitable |
| NCBI accession no.【NCBI登记号】 | NP_003099 |
| UniProt accession no.【UniProt登记号】 | P35716 |
| shipped in【运输】 | wet ice |
| Gene Information | human ... SOX11(6664) |
产品说明
| Target description【目标描述】 | ~57 kDa observed |
| Storage and Stability【储存及稳定性】 | Stable for 1 year at 2-8°C from date of receipt. |
| Disclaimer【免责声明】 | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
安全信息
| Storage Class Code【储存分类代码】 | 12 - Non Combustible Liquids |
| WGK | WGK 1 |
