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Anti-Rab7A, clone 5G8.1 Antibody

产品编号:4113385
规格:clone 5G8.1, 0.5 mg/mL, from mouse
包装规格:100 μL
产品类别:进口试剂
品牌:Sigma-Aldrich
优惠价:立即咨询
产品价格
产品编号包装单位单价(元)国内现货国外库存询价单
4113385100 μL6020
产品别名

Anti-Rab7A, clone 5G8.1 Antibody

Ras-related protein Rab-7a

基本信息
eCl@ss
32160702
NACRES
NA.41
General description【一般描述】
Ras-related protein Rab-7A (Rab7A, RAB7) is a small intracellular protein typically associated with cytoplasmic vesicles, phagosomes, and endosomes and is expressed in most cells but particularly high in muscle. It plays an important role in regulating the endo-lysosomal trafficking of proteins as well as in the endosomal trapping of pathogens and viruses. Besides endosome-lysosome trafficking, Rab7A functions in a variety of other critical cellular processes including nutrient uptake, growth factor mediated growth, neurotrophin transport, lipid transport, lysosome and phagosome maturation and development, as well as pathogen and virus innate immunity functions. RAB7A interacts with a number of other proteins within the cell, some important in endosome trafficking like RILP (Rab-interacting lysosomal protein) and CHM (Rab escort protein 1) others like RAC1 have a more pleiotropic impact and are part of many cellular processes, including the cell cycle, cell-cell adhesion, cytoskeletal motility, and cellular differentiation.
Immunogen【免疫原】
GST-tagged recombinant protein corresponding to human Rab7A.
Application【应用】
Detect Rab7A using this Anti-Rab7A antibody, clone 5G8.1 validated for use in western blotting & IHC.
Research Sub Category
Apoptosis - Additional
Research Category
Apoptosis & Cancer
Immunohistochemistry Analysis: A 1:50 dilution from a representative lot detected Rab7A in human breast cancer and human cardiac myocytes and lymphocytes in human heart tissue.
Quality【质量】
Evaluated by Western Blotting in SK-MEL28 cell lysate.

Western Blotting Analysis: A 1:2,000 dilution of this antibody detected Rab7A in 10 µg of SK-MEL28 cell lysate.
Physical form【外形】
Purified mouse monoclonal IgG2bκ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Format: Purified
Protein G Purified
产品性质
Quality Level【质量水平】
100
biological source【生物来源】
mouse
antibody form【抗体形式】
purified immunoglobulin
antibody product type
primary antibodies
clone【克隆】
5G8.1, monoclonal
species reactivity
human
concentration【浓度】
0.5 mg/mL
technique(s)
immunohistochemistry: suitable
western blot: suitable
isotype【同位素/亚型】
IgG2bκ
NCBI accession no.【NCBI登记号】
NP_004628
UniProt accession no.【UniProt登记号】
P51149
shipped in【运输】
wet ice
Gene Information
human ... RAB7A(7879)
产品说明
Target description【目标描述】
~23 kDa observed
Storage and Stability【储存及稳定性】
Stable for 1 year at 2-8°C from date of receipt.
Disclaimer【免责声明】
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
安全信息
Storage Class Code【储存分类代码】
12 - Non Combustible Liquids
WGK
WGK 1
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