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Anti-Piccolo Antibody, clone 4G3.3
产品别名
Anti-Piccolo Antibody, clone 4G3.3
presynaptic cytomatrix protein, Aczonin
基本信息
| eCl@ss | 32160702 |
| NACRES | NA.41 |
| General description【一般描述】 | Piccolo (presynaptic cytomatrix protein or PCLO) may act as a scaffolding protein involved in the organization of synaptic active zones. Synaptic vesicles dock and fuse in the active zone of the plasma membrane at chemical synapses. The presynaptic cytoskeletal matrix (PCM), which is associated with the active zone and is situated between synaptic vesicles, is thought to be involved in maintaining the neurotransmitter release site in register with the postsynaptic reception apparatus. The cycling of synaptic vesicles is a multistep process involving a number of proteins. Among the components of the PCM that orchestrate these events are Bassoon (BSN), RIM (RBBP8), Oboe, and Piccolo (PCLO) [supplied by ENTREZGENE]. |
| Specificity【特异性】 | This antibody recognizes piccolo. |
| Immunogen【免疫原】 | GST-tagged recombinant protein |
| Application【应用】 | Immunohistochemistry (Paraffin): Representative images from a previous lot. Piccolo staining pattern/morphology on mouse brain tissue/cerebellum. Tissue was pretreated with citrate pH 6.0, antigen retrieval. A previous lot of the antibody was diluted to 1:300, using IHC-Select Research Sub Category Synapse & Synaptic Biology This Anti-Piccolo Antibody, clone 4G3.3 is validated for use in WB, IH(P) for the detection of Piccolo. Research Category Neuroscience |
| Quality【质量】 | Routinely evaluated by western blot on rat brain lysate. |
| Physical form【外形】 | Format: Purified Purified mouse monoclonal IgMκ in buffer containing PBS and 0.05% sodium azide. Ammonium Sulfate Precipitation |
| Analysis Note【分析说明】 | Control Rat brain lysate, mouse cerebellum |
| Other Notes【其他说明】 | Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration. |
产品性质
| Quality Level【质量水平】 | 100 |
| biological source【生物来源】 | mouse |
| antibody form【抗体形式】 | purified antibody |
| antibody product type | primary antibodies |
| clone【克隆】 | 4G3.3, monoclonal |
| species reactivity | mouse |
| species reactivity (predicted by homology) | rat (92% homology), human (based on 82% homology) |
| technique(s) | immunohistochemistry: suitable (paraffin) western blot: suitable |
| isotype【同位素/亚型】 | IgMκ |
| NCBI accession no.【NCBI登记号】 | NP_001104266 |
| UniProt accession no.【UniProt登记号】 | Q9Y6V0 |
| shipped in【运输】 | wet ice |
产品说明
| Target description【目标描述】 | 547 kDa |
| Storage and Stability【储存及稳定性】 | Stable for 1 year at 2-8°C from date of receipt. |
| Disclaimer【免责声明】 | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
安全信息
| Storage Class Code【储存分类代码】 | 12 - Non Combustible Liquids |
| WGK | WGK 2 |
