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Anti-PICALM Antibody
| 产品编号： | 4112782 |
| 规格： | from rabbit, purified by affinity chromatography |
| 包装规格： | 100 μG |
| 产品类别： | 进口试剂 |
| 品牌： | Sigma-Aldrich |
| 优惠价： | 立即咨询 |
产品别名
Anti-PICALM Antibody
Phosphatidylinositol-binding clathrin assembly protein, LAP, CALM, CLTH, Clathrin assembly lymphoid myeloid leukemia protein
基本信息
| eCl@ss | 32160702 |
| NACRES | NA.41 |
| General description【一般描述】 | Phosphatidylinositol-binding clathrin assembly protein (PICALM), also known as the clathrin assembly lymphoid myeloid leukemia (CALM) protein, co-localizes with clathrin at clathrin-coated areas of the plasma membrane and in the Golgi area as a component of the coated pit internalization machinery. PICALM fusion proteins have been implicated in acute myeloid and T-cell acute lymphoblastic leukemia, and chromosomal aberrations are found in diffuse histiocytic lymphomas. PICALM is also expressed in neuronal synapses where it facilitates the endocytosis of VAMP2. PICALM variants are associated with Alzheimer′s disease and are thought to be involved in the endocytosis and recycling of the amyloid protein precursor (APP). |
| Specificity【特异性】 | This antibody can recognize all isoforms of PICALM. |
| Immunogen【免疫原】 | KLH-conjugated linear peptide corresponding to human PICALM. |
| Application【应用】 | Research Category Neuroscience Anti-PICALM Antibody is a highly specific rabbit polyclonal antibody, that targets Phosphatidylinositol-binding clathrin assembly protein & has been tested in western blotting. Research Sub Category Neurodegenerative Diseases |
| Quality【质量】 | Evaluated by Western Blotting in EL4 cell lysate. Western Blotting Analysis: 1 µg/mL of this antibody detected PICALM in 15 µg of EL4 cell lysate. |
| Physical form【外形】 | Purified rabbit polyclonal in buffer containing PBS with up to 0.1% sodium azide. Antigen Affinity Purified |
| Analysis Note【分析说明】 | Control EL4 cell lysate |
| Other Notes【其他说明】 | Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration. |
产品性质
| biological source【生物来源】 | rabbit |
| Quality Level【质量水平】 | 100 |
| antibody form【抗体形式】 | affinity isolated antibody |
| antibody product type | primary antibodies |
| clone【克隆】 | polyclonal |
| purified by【纯化方式】 | affinity chromatography |
| species reactivity | mouse |
| species reactivity (predicted by homology) | human (immunogen homology) |
| technique(s) | western blot: suitable |
| UniProt accession no.【UniProt登记号】 | Q13492 |
| shipped in【运输】 | wet ice |
| Gene Information | human ... PICALM(8301) |
产品说明
| Target description【目标描述】 | ~62 kDa and ~71 kDa observed. Uncharacterized bands may appear in some lysate(s). Uniprot describes 5 isoforms between ~60 kDa and ~71 kDa |
| Storage and Stability【储存及稳定性】 | Stable for 1 year at 2-8°C from date of receipt. |
| Disclaimer【免责声明】 | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
安全信息
| Storage Class Code【储存分类代码】 | 10 - Combustible liquids |
| WGK | WGK 2 |
