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Anti-Phospho-PLN-S16 antibody produced in rabbit

产品编号:4112594
包装规格:100 μL
产品类别:进口试剂
品牌:Sigma-Aldrich
优惠价:立即咨询
产品价格
产品编号包装单位单价(元)国内现货国外库存询价单
4112594100 μL4710
产品别名

Anti-Phospho-PLN-S16 antibody produced in rabbit

CMD1P

PLB

PLN

CMH18

产品性质
biological source【生物来源】
rabbit
Quality Level【质量水平】
100
antibody form【抗体形式】
affinity isolated antibody
antibody product type
primary antibodies
clone【克隆】
polyclonal
form【形式】
buffered aqueous solution
mol wt【分子量】
6
species reactivity
rat, human, mouse
concentration【浓度】
0.65 mg/ml
technique(s)
western blot: 1:500-1:2000
UniProt accession no.【UniProt登记号】
P26678
shipped in【运输】
wet ice
storage temp.【储存温度】
−20℃
Gene Information
human ... PLN(5350)
基本信息
General description【一般描述】
The protein encoded by this gene is found as a pentamer and is a major substrate for the cAMP-dependent protein kinase in cardiac muscle. The encoded protein is an inhibitor of cardiac muscle sarcoplasmic reticulum Ca(2+)-ATPase in the unphosphorylated state, but inhibition is relieved upon phosphorylation of the protein. The subsequent activation of the Ca(2+) pump leads to enhanced muscle relaxation rates, thereby contributing to the inotropic response elicited in heart by beta-agonists. The encoded protein is a key regulator of cardiac diastolic function. Mutations in this gene are a cause of inherited human dilated cardiomyopathy with refractory congestive heart failure, and also familial hypertrophic cardiomyopathy.
Immunogen【免疫原】
A phospho specific peptide corresponding to residues surrounding S16 of human PLN
Physical form【外形】
PBS with 0.02% sodium azide,50% glycerol,pH7.3.
产品说明
Storage and Stability【储存及稳定性】
Store at -20℃. Avoid freeze / thaw cycles.
安全信息
Storage Class Code【储存分类代码】
12 - Non Combustible Liquids
WGK
WGK 1
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