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Anti-Phospho-PKCalpha/beta II-T638/641 antibody produced in rabbit
产品性质
biological source【生物来源】 | rabbit |
Quality Level【质量水平】 | 100 |
antibody product type | primary antibodies |
clone【克隆】 | polyclonal |
form【形式】 | liquid |
species reactivity | human |
concentration【浓度】 | 2.54 mg/mL |
technique(s) | western blot: 1:500-1:2000 |
UniProt accession no.【UniProt登记号】 | P17252/P05771 |
shipped in【运输】 | wet ice |
storage temp.【储存温度】 | −20℃ |
基本信息
General description【一般描述】 | Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC family members also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play a distinct role in cells. The protein encoded by this gene is one of the PKC family members. This protein kinase has been reported to be involved in many different cellular functions, such as B cell activation, apoptosis induction, endothelial cell proliferation, and intestinal sugar absorption. Studies in mice also suggest that this kinase may also regulate neuronal functions and correlate fear-induced conflict behavior after stress. Alternatively spliced transcript variants encoding distinct isoforms have been reported. |
Immunogen【免疫原】 | A phospho specific peptide corresponding to residues surrounding T638/641 of human PKCalpha/beta II |
Physical form【外形】 | Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3. |