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Anti-Phospho-PKA RIIα (PRKAR2A)-S99 antibody produced in rabbit

产品编号:4112571
产品类别:进口试剂
品牌:Sigma-Aldrich
优惠价:立即咨询
产品价格
产品编号包装单位单价(元)国内现货国外库存询价单
41125715400
产品性质
biological source【生物来源】
rabbit
Quality Level【质量水平】
100
antibody product type
primary antibodies
clone【克隆】
monoclonal
form【形式】
liquid
species reactivity
human
concentration【浓度】
0.95 mg/mL
technique(s)
western blot: 1:500-1:2000
UniProt accession no.【UniProt登记号】
P13861
shipped in【运输】
wet ice
storage temp.【储存温度】
−20℃
Gene Information
human ... PRKAR2A(5576)
基本信息
General description【一般描述】
cAMP is a signaling molecule important for a variety of cellular functions. cAMP exerts its effects by activating the cAMP-dependent protein kinase, which transduces the signal through phosphorylation of different target proteins. The inactive kinase holoenzyme is a tetramer composed of two regulatory and two catalytic subunits. cAMP causes the dissociation of the inactive holoenzyme into a dimer of regulatory subunits bound to four cAMP and two free monomeric catalytic subunits. Four different regulatory subunits and three catalytic subunits have been identified in humans. The protein encoded by this gene is one of the regulatory subunits. This subunit can be phosphorylated by the activated catalytic subunit. It may interact with various A-kinase anchoring proteins and determine the subcellular localization of cAMP-dependent protein kinase. This subunit has been shown to regulate protein transport from endosomes to the Golgi apparatus and further to the endoplasmic reticulum (ER). [provided by RefSeq, Jul 2008]
Immunogen【免疫原】
A phospho specific peptide corresponding to residues surrounding S99 of human PRKAR2A/PKR2
Physical form【外形】
Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3.
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