广州伟伯科技有限公司
您的位置:首页 > 产品中心 > Anti-Phospho-NCF4-T154 antibody produced in rabbit
产品搜索:

Anti-Phospho-NCF4-T154 antibody produced in rabbit

产品编号:4112509
产品类别:进口试剂
品牌:Sigma-Aldrich
优惠价:立即咨询
产品价格
产品编号包装单位单价(元)国内现货国外库存询价单
41125095400
产品性质
biological source【生物来源】
rabbit
Quality Level【质量水平】
100
antibody product type
primary antibodies
clone【克隆】
polyclonal
form【形式】
liquid
species reactivity
rat, mouse, human
concentration【浓度】
0.34 mg/mL
technique(s)
western blot: 1:500-1:2000
UniProt accession no.【UniProt登记号】
Q15080
shipped in【运输】
wet ice
storage temp.【储存温度】
−20℃
Gene Information
human ... NCF4(4689)
基本信息
General description【一般描述】
The protein encoded by this gene is a cytosolic regulatory component of the superoxide-producing phagocyte NADPH-oxidase, a multicomponent enzyme system important for host defense. This protein is preferentially expressed in cells of myeloid lineage. It interacts primarily with neutrophil cytosolic factor 2 (NCF2/p67-phox) to form a complex with neutrophil cytosolic factor 1 (NCF1/p47-phox), which further interacts with the small G protein RAC1 and translocates to the membrane upon cell stimulation. This complex then activates flavocytochrome b, the membrane-integrated catalytic core of the enzyme system. The PX domain of this protein can bind phospholipid products of the PI(3) kinase, which suggests its role in PI(3) kinase-mediated signaling events. The phosphorylation of this protein was found to negatively regulate the enzyme activity. Alternatively spliced transcript variants encoding distinct isoforms have been observed.
Immunogen【免疫原】
A synthetic phosphorylated peptide around T154 of human NCF4.
Physical form【外形】
Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
广州伟伯科技有限公司 版权所有 CopyRight ©2006-2024, All Rights Reserved
工信部备案号:粤ICP备08114744号   Page Run Time: 0.0227