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Anti-LZTR2 Antibody
| 产品编号： | 4109942 |
| 规格： | from rabbit, purified by affinity chromatography |
| 包装规格： | 100 μG |
| 产品类别： | 进口试剂 |
| 品牌： | Sigma-Aldrich |
| 优惠价： | 立即咨询 |
产品别名
Anti-LZTR2 Antibody
Leucine zipper-like transcription regulator 2, SEC16B, RGPR, RGPR-p117, KIAA1928, LZTR2, SEC16S, Regucalcin gene promoter region-related protein p117, Protein transport protein Sec16B, SEC16 homolog B
基本信息
| eCl@ss | 32160702 |
| NACRES | NA.41 |
| General description【一般描述】 | Leucine zipper-like transcription regulator 2 (LZTR2), also known as RGPR-p117, is a member of the SEC16 family and BTB-kelch superfamily. LZTR2 is required for secretory cargo traffic from the endoplasmic reticulum to the Golgi apparatus and for normal transitional endoplasmic reticulum (tER) organization. Initially, it was described as a nuclear factor I (NFI) binding protein and transcriptional regulator of the regucalcin gene. LZTR2 is localized in the cytoplasm but is thought to translocate to the nucleus following a hormonal stimulation and mediated by protein kinase C signaling. Recent studies has suggested that there is a strong correlation between LZTR2 and obesity in the Japanese population similar to that seen with the TMEM18 gene and the GNPDA2, BDNF, FAIM2, and MC4R genes with obesity in Caucasian populations. This evidence implies that LZTR2 may play an important role in metabolism and obesity risk. |
| Immunogen【免疫原】 | KLH-conjugated linear peptide corresponding to human LZTR2. |
| Application【应用】 | Research Sub Category Metabolic Hormones & Receptors Research Category Signaling Anti-LZTR2 Antibody is a highly specific rabbit polyclonal antibody, that targets Leucine zipper-like transcription regulator 2 & has been tested in western blotting & IHC. Immunohistochemistry Analysis: 5 µg/mL from a representative lot detected LZTR2 in mouse kidney tissue. |
| Quality【质量】 | Evaluated by Western Blotting in mouse kidney tissue lysate. Western Blotting Analysis: 1 µg/mL of this antibody detected LZTR2 in 15 µg of mouse kidney tissue lysate. |
| Physical form【外形】 | Purified rabbit polyclonal in buffer containing PBS with up to 0.1% sodium azide. Antigen Affinity Purified |
| Analysis Note【分析说明】 | Control Mouse kidney tissue lysate |
| Other Notes【其他说明】 | Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration. |
产品性质
| biological source【生物来源】 | rabbit |
| Quality Level【质量水平】 | 100 |
| antibody form【抗体形式】 | affinity isolated antibody |
| antibody product type | primary antibodies |
| clone【克隆】 | polyclonal |
| purified by【纯化方式】 | affinity chromatography |
| species reactivity | mouse |
| species reactivity (predicted by homology) | human (immunogen homology) |
| technique(s) | immunohistochemistry: suitable western blot: suitable |
| UniProt accession no.【UniProt登记号】 | Q96JE7 |
| shipped in【运输】 | wet ice |
| Gene Information | human ... SEC16B(89866) |
产品说明
| Target description【目标描述】 | ~92 kDa and ~140 kDa observed. Uncharacterized bands may appear in some lysate(s). Uniprot describes 3 isoforms at ~59 kDa, ~71 kDa, and ~117 kDa |
| Storage and Stability【储存及稳定性】 | Stable for 1 year at 2-8°C from date of receipt. |
| Disclaimer【免责声明】 | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
安全信息
| Storage Class Code【储存分类代码】 | 10 - Combustible liquids |
| WGK | WGK 2 |
