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Anti-Lnk/SH2B adapter protein 3 Antibody
| 产品编号： | 4109820 |
| 规格： | from rabbit, purified by affinity chromatography |
| 包装规格： | 100 μG |
| 产品类别： | 进口试剂 |
| 品牌： | Sigma-Aldrich |
| 优惠价： | 立即咨询 |
产品别名
Anti-Lnk/SH2B adapter protein 3 Antibody
SH2B adapter protein 3, Lymphocyte adapter protein, Lymphocyte-specific adapter protein Lnk, Signal transduction protein Lnk
基本信息
| eCl@ss | 32160702 |
| NACRES | NA.41 |
| General description【一般描述】 | Lnk is an SH2B3 multidomain adaptor protein that is primarily expressed in lymphocytes. It contains the characteristic pleckstrin homology (PH); src homology 2 (SH2); dimerization; and proline-rich domains. Lnk functions as a negative regulator of B cell proliferative processes via interaction with Jak2 and Mpl proteins, and inhibition of the PI3/Akt/STAT5 signaling pathway. Previous studies have implicated Lnk in celiac disease type 13. |
| Specificity【特异性】 | This antibody recognizes Lnk/SH2B adapter protein 3 at the C-terminus. Other homologies: Rat (78% sequence homology) and Mouse (72% sequence homology). |
| Immunogen【免疫原】 | Epitope: C-terminus KLH-conjugated linear peptide corresponding to the C-terminus of human Lnk/SH2B adapter protein 3. |
| Application【应用】 | Research Category Cell Structure Detect the Lnk/SH2B adapter protein 3 protein using this Anti-Lnk/SH2B adapter protein 3 validated for use in WB. Research Sub Category Adhesion (CAMs) |
| Quality【质量】 | Evaluated by Western Blot in HepG2 cell lysate. Western Blot Analysis: 0.5 µg/mL of this antibody detected Lnk/SH2B adapter protein 3 on 10 µg of HepG2 cell lysate. |
| Physical form【外形】 | Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide. Affinity purified |
| Analysis Note【分析说明】 | Control HepG2 cell lysate |
| Other Notes【其他说明】 | Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration. |
产品性质
| biological source【生物来源】 | rabbit |
| Quality Level【质量水平】 | 100 |
| antibody form【抗体形式】 | affinity isolated antibody |
| antibody product type | primary antibodies |
| clone【克隆】 | polyclonal |
| purified by【纯化方式】 | affinity chromatography |
| species reactivity | human |
| technique(s) | western blot: suitable |
| NCBI accession no.【NCBI登记号】 | NP_005466 |
| UniProt accession no.【UniProt登记号】 | Q9UQQ2 |
| shipped in【运输】 | wet ice |
| Gene Information | human ... SH2B3(10019) |
产品说明
| Target description【目标描述】 | ~80 kDa observed. The calculated molecular weight is 63 kDa, however Lnk/SH2B adapter protein 3 has been shown as a ~80 kDa band in western blots (Li, Y., et al. (2000). J Immunol. 164:5199-5206.) |
| Storage and Stability【储存及稳定性】 | Stable for 1 year at 2-8°C from date of receipt. |
| Disclaimer【免责声明】 | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
安全信息
| Storage Class Code【储存分类代码】 | 12 - Non Combustible Liquids |
| WGK | WGK 1 |
