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Anti-Integrin beta1 Antibody, clone HM beta 1.1
产品别名
Anti-Integrin beta1 Antibody, clone HM beta 1.1
CD29 antigen, Fibronectin receptor subunit beta, Integrin VLA-4 subunit beta, fibronectin receptor beta subunit, integrin VLA-4 beta subunit, integrin beta 1, integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen
CD29 includes MDF2,
基本信息
| eCl@ss | 32160702 |
| NACRES | NA.41 |
| General description【一般描述】 | Integrin beta 1is also known as CD29. It is a transmembrane glycoprotein that forms noncovalent complexes with various Integrin alpha subunits, forming the functional receptors that bind to specific extracellular matrix proteins. Integrin receptors are involved in the regulation of a variety of important biological functions such as hemostasis, embryonic development, wound repair, and prevention of programmed cell death. They are also implicated in abnormal pathological states such as tumor directed angiogenesis, tumor cell growth, and metastasis. These heterodimeric receptors bridge the cytoplasmic actin cytoskeleton with proteins present in the extracellular matrix and on adjacent cells. The clustering of integrins on a cell surface leads to the formation of focal contacts. Interactions between integrins and the extracellular matrix lead to activation of signal transduction pathways and regulation of gene expression. Clone HM beta 1.1 is reported to inhibit beta 1 integrin mediated adhesion. |
| Specificity【特异性】 | Other species have not been tested. |
| Immunogen【免疫原】 | Epitope: Full length Purified mouse VLA-4 antigen |
| Application【应用】 | Research Category Cell Structure Research Sub Category Integrins Detect Integrin beta1 using this Anti-Integrin beta1 Antibody, clone HM beta 1.1 validated for use in IC. |
| Quality【质量】 | Routinely evaluated by immunocytochemistry on mouse NIH3T3, A431 cells. |
| Physical form【外形】 | Purified in PBS with 0.05% NaN3. Format: Purified Protein G Purified |
| Analysis Note【分析说明】 | Control NIH3T3, A431 |
| Other Notes【其他说明】 | Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration. |
产品性质
| Quality Level【质量水平】 | 100 |
| biological source【生物来源】 | hamster |
| antibody form【抗体形式】 | purified antibody |
| antibody product type | primary antibodies |
| clone【克隆】 | HM beta 1.1, monoclonal |
| species reactivity | mouse, human |
| technique(s) | immunocytochemistry: suitable |
| isotype【同位素/亚型】 | IgG |
| NCBI accession no.【NCBI登记号】 | NP_002202.2 |
| UniProt accession no.【UniProt登记号】 | P09055 |
| shipped in【运输】 | wet ice |
产品说明
| Target description【目标描述】 | 130 kDa |
| Storage and Stability【储存及稳定性】 | Maintain at 2-8°C in undiluted aliquots for up to 1 year after date of receipt. |
| Disclaimer【免责声明】 | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
安全信息
| Storage Class Code【储存分类代码】 | 10 - Combustible liquids |
| WGK | WGK 2 |
