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Anti-Integrin beta-3 (CD61) Antibody, clone HMb3-1
产品别名
Anti-Integrin beta-3 (CD61) Antibody, clone HMb3-1
CD61 antigen, Platelet membrane glycoprotein IIIa, integrin beta chain, beta 3, integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61), platelet glycoprotein IIIa, GPIIIa
基本信息
| eCl@ss | 32160702 |
| NACRES | NA.41 |
| General description【一般描述】 | The integrin family of cell adhesion receptors consists of several membrane-associated heterodimers, composed of an alpha and beta subunit that associate in a non-covalent manner. The structure and functional diversity of the integrin family are based upon the pairing abilities of the individual alpha and beta subunits. Key to these molecular interactions between the integrin receptors and their respective ligands is the recognition of the Arg-Gly-Asp (RGD) sequence, known to be present in the extracellular matrix components fibronectin, vitronectin, collagen, fibrinogen, and von Willebrand factor. The involvement of integrins in vascular proliferation, adhesion, and wound repair has been well documented. Platelet membrane glycoprotein Integrin beta3 or CD61 (GP IIIa) forms a Ca2+-dependent heterodimer complex with GP IIb. The GP IIb-IIIa complex constitutes the fibrinogen and fibronectin receptor on stimulated platelets. |
| Specificity【特异性】 | The antibody recognizes Integrin beta-3. |
| Immunogen【免疫原】 | Recombinant protein corresponding to mouse Integrin beta-3. |
| Application【应用】 | Detect Integrin beta-3 (CD61) using this Anti-Integrin beta-3 (CD61) Antibody, clone HMb3-1 validated for use in FC, IH. Immunohistochemistry Analysis: A previous lot was used by an independent laboratory in IH (Piali, 1995). |
| Quality【质量】 | Evaluated by Flow Cytometry on mouse bone marrow-derived cells. Flow Cytometry Analysis: 0.1-1 µg/mL of the antibody detected Integrin beta-3 on mouse bone marrow-derived cells |
| Physical form【外形】 | Protein G Purified Format: Purified |
| Analysis Note【分析说明】 | Control Mouse bone marrow-derived cells |
| Other Notes【其他说明】 | Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration. |
产品性质
| biological source【生物来源】 | hamster (Armenian) |
| Quality Level【质量水平】 | 100 |
| antibody form【抗体形式】 | purified immunoglobulin |
| antibody product type | primary antibodies |
| clone【克隆】 | HMb3-1, monoclonal |
| species reactivity | mouse |
| technique(s) | flow cytometry: suitable immunohistochemistry: suitable |
| isotype【同位素/亚型】 | IgG |
| NCBI accession no.【NCBI登记号】 | NP_058060.2 |
| UniProt accession no.【UniProt登记号】 | O54890 |
| shipped in【运输】 | wet ice |
产品说明
| Target description【目标描述】 | ~ 86-87 kDa |
| 【免责声明】 | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
安全信息
| Storage Class Code【储存分类代码】 | 12 - Non Combustible Liquids |
| WGK | WGK 1 |
