Anti-Integrin α6B Antibody, cytoplasmic domain, clone 6B4

32160702

NA.41

Integrins are a family of heterodimeric membrane glycoproteins consisting of non-covalently associated alpha and beta subunits. More than 18 alpha and 8 beta subunits with numerous splice variant isoforms have been identified in mammals. In general, integrin function as receptors for extracellular matrix proteins. Certain integrins can also bind to soluble ligands or to counter-receptors on adjacent cells, such as the intracellular adhesion molecules (ICAMs), resulting in aggregation of cells. Signals transduced by integrins play a role in many biological processes, including cell growth, differentiation, migration and apoptosis. For integrin subunits alpha 3 and alpha6, two cytoplasmic variants, A and B, have been identified.

MAB1358 recognizes specifically the cytoplasmic domain of integrin subunit alpha 6B. The antibody stains the basement membrane zone of ducts and acini of salivary gland, kidney tubules, epithelium of colonic crypts and weakly stains sweat glands and sebaceous glands.

Broad species reactivity is expected due to the conserved nature of the epitope.

Synthetic Peptide to the cytoplasmic domain of integrin subunit alpha6B including an appending N-terminal cysteine: CSRYDDSVPRYHAVRIRKEEREIKDEKYIDNLEKK

Anti-Integrin α6B Antibody, cytoplasmic domain, clone 6B4 is an antibody against Integrin α6B for use in WB, IC, IH.
Western blotting: 1:100-1:500

Immunocytochemistry: 1:100-1:500 on frozen sections, 1:50-1:100 with avidin-biotin complex detection

Immunocytochemistry

Optimal working dilutions must be determined by the end user.

Format: Purified

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany

100

mouse

purified immunoglobulin

primary antibodies

6B4, monoclonal

human

Chemicon^®

immunocytochemistry: suitable
immunohistochemistry: suitable
western blot: suitable

IgG1

NM_000210.2
NM_001079818.1

P23229

wet ice

human ... ITGA6(3655)

Store at 2-8°C, or -20°C in small aliquots for up to 12 months after date of receipt. Avoid freeze/thaw cycles.

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

12 - Non Combustible Liquids

WGK 2