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Anti-IL-31 Antibody
| 产品编号： | 4109166 |
| 规格： | from rabbit, purified by affinity chromatography |
| 包装规格： | 100 μG |
| 产品类别： | 进口试剂 |
| 品牌： | Sigma-Aldrich |
| 优惠价： | 立即咨询 |
产品别名
Anti-IL-31 Antibody
Interleukin 31, IL-31
基本信息
| eCl@ss | 32160702 |
| NACRES | NA.41 |
| General description【一般描述】 | Interleukin-31 (IL-31) is a T-cell cytokine that activates STAT3 and possibly STAT1 and STAT5 through the IL-31 heterodimeric receptor composed of IL31RA and OSMR. IL-31 is similar to IL-6 type cytokines and is produced mainly by T helper type 2 cells. The ligand-induced oligomerization of a dimeric receptor complex containing IL-31 receptor A and oncostatin M receptor is the mediator of IL-31 activity. These proteins activate the JAK/STAT and the AKT signaling pathways in response to IL-31 binding. RNA levels of IL-31 receptor A and oncostatin M receptor are induced in activated monocytes and expressed highly in epithelial cells. Overexpression of IL-31 in transgenic mice results in the development of pruritis, alopecia, and skin lesions. Mutations of IL-31 in humans may result in atopic dermatitis, suggesting that IL-31 may play a role in skin immunity and may represent a novel target for antipruritic drug development. |
| Specificity【特异性】 | This antibody recognizes the N-terminus of IL-31. |
| Immunogen【免疫原】 | Epitope: N-terminus KLH-conjugated linear peptide corresponding to the N-terminus of human IL-31. |
| Application【应用】 | Immunohistochemistry Analysis: 10 µg/mL from a representative lot detected IL-31 in rat skeletal muscle tissue. Anti-IL-31 Antibody is a highly specific rabbit polyclonal antibody, that targets IL-31 & has been tested in western blotting & IHC. Research Category Signaling Research Sub Category Developmental Signaling |
| Quality【质量】 | Evaluated by Western Blotting in RAW264.7 cell lysate. Western Blotting Analysis: 2.5 µg/mL of this antibody detected IL-31 in 15 µg of RAW264.7 cell lysate. |
| Physical form【外形】 | Purified rabbit polyclonal in buffer containing PBS with up to 0.1% sodium azide. Antigen Affinity Purified |
| Analysis Note【分析说明】 | Control RAW264.7 cell lysate |
| Other Notes【其他说明】 | Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration. |
产品性质
| biological source【生物来源】 | rabbit |
| Quality Level【质量水平】 | 100 |
| antibody form【抗体形式】 | affinity isolated antibody |
| antibody product type | primary antibodies |
| clone【克隆】 | polyclonal |
| purified by【纯化方式】 | affinity chromatography |
| species reactivity | rat, mouse |
| species reactivity (predicted by homology) | human (immunogen homology) |
| technique(s) | immunohistochemistry: suitable western blot: suitable |
| UniProt accession no.【UniProt登记号】 | Q6EAL8 |
| shipped in【运输】 | wet ice |
产品说明
| Target description【目标描述】 | ~30 kDa observed. Uncharacterized bands may appear in some lysate(s). |
| Storage and Stability【储存及稳定性】 | Stable for 1 year at 2-8°C from date of receipt. |
| Disclaimer【免责声明】 | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
安全信息
| Storage Class Code【储存分类代码】 | 10 - Combustible liquids |
| WGK | WGK 2 |
