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Anti-hnRNP Q Antibody, clone 7A11.2
产品别名
Anti-hnRNP Q Antibody, clone 7A11.2
heterogeneous nuclear ribonucleoprotein Q-like, Synaptotagmin-binding, cytoplasmic RNA-interacting protein, Glycine- and tyrosine-rich RNA-binding protein, GRY-RBP, NS1-associated protein 1
基本信息
| eCl@ss | 32160702 |
| NACRES | NA.41 |
| General description【一般描述】 | Heterogeneous nuclear ribonucleoprotein Q, commonly refered to as hnRNP Q, can be found as three different isoforms derived from alternative splicing of a single gene. This RNA binding protein is implicated in control of mRNA precursor splicing for the survival of motor neurons (SMN) protein. Loss-of-function mutations of SMN are linked to spinal muscular atrophy (SMA) a common neurodegenerative disease. It has been shown that hnRNP Q proteins interact with SMN, and this is interacton is required for efficient pre-mRNA splicing in vitro. Current data suggests that hnRNP Q is a splicing modulator of SMN. |
| Immunogen【免疫原】 | Full length recombinant protein corresponding to human hnRNPQ. |
| Application【应用】 | Western Blot Analysis: 1 µg/mL from a representative lot detected hnRNP Q on 10 µg of PC-12 and HEK293 cell lysate. Immunocytochemistry Analysis: 1:500 dilution from a representative lot detected hnRNP Q in NIH/3T3, A431, and HeLa cells. Anti-hnRNP Q Antibody, clone 7A11.2 is a Mouse Monoclonal Antibody for detection of hnRNP Q also known as heterogeneous nuclear ribonucleoprotein Q-like & has been validated in WB, ICC. |
| Quality【质量】 | Evaluated by Western Blot in NIH/3T3 cell lysate. Western Blot Analysis: 1 µg/mL of this antibody detected hnRNP Q on 10 µg of NIH/3T3 cell lysate. |
| Physical form【外形】 | Protein G Format: Purified |
| Other Notes【其他说明】 | Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration. |
产品性质
| Quality Level【质量水平】 | 100 |
| biological source【生物来源】 | mouse |
| antibody form【抗体形式】 | purified immunoglobulin |
| antibody product type | primary antibodies |
| clone【克隆】 | 7A11.2, monoclonal |
| species reactivity | rat, mouse, human |
| technique(s) | immunocytochemistry: suitable western blot: suitable |
| isotype【同位素/亚型】 | IgG1κ |
| NCBI accession no.【NCBI登记号】 | NP_001153145 |
| UniProt accession no.【UniProt登记号】 | O60506 |
| shipped in【运输】 | wet ice |
| Gene Information | human ... SYNCRIP(10492) |
产品说明
| Target description【目标描述】 | ~59 observed. Mulitple isoforms may be observed in some lysates. |
| 【免责声明】 | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
安全信息
| Storage Class Code【储存分类代码】 | 12 - Non Combustible Liquids |
| WGK | WGK 1 |
